中老年男性动脉弹性与血清尿酸及血脂的相关性  

Correlation of arterial elasticity with the levels of serum uric acid and blood lipid in the middle-aged and elderly male population

作　　者：史晓雪[1] 唐世琪[1] 徐丽娟[1] 刘静[1] 王瑾[2] 刘化云 Shi Xiaoxue;Tang Shiqi;Xu Lijuan;Liu Jing;Wang Jin;Liu Huayun(Department of Geriatrics,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院老年医学科,武汉430060 [2]武汉大学人民医院体验中心,武汉430060

出　　处：《中国临床保健杂志》2018年第2期164-167,共4页Chinese Journal of Clinical Healthcare

基　　金：湖北省攻关计划项目(2015BKA335)

摘　　要：目的研究中老年男性动脉弹性与血清尿酸及血脂水平的相关性。方法选取男性体检者279例,进行体格、生化及动脉弹性检查,根据脉搏波传导速度(PWV)测定分为动脉硬化组138例,非动脉硬化组141例,分析动脉弹性与血清尿酸、血脂水平之间的相关性。结果与非动脉硬化对照组比较,动脉硬化组血清尿酸[(409.38±92.78)mmol/L比(433.84±93.43)mmol/L]、三酰甘油(TG)[(1.64±0.83)mmol/L比(2.26±1.37)mmol/L]水平显著升高(P<0.05或P<0.01),而低密度脂蛋白(LDL)、高密度脂蛋白(HDL)及总胆固醇(TCH)水平差异无统计学意义。Pearson相关性分析显示,年龄、腰围、TG与肱-踝脉搏波传导速度存在明显的正相关(r=0.169~0.439,P<0.05或P<0.01)。结论 TG水平与动脉硬化密切相关,同时高尿酸血症、肥胖、高血压及血糖异常是中老年男性动脉硬化的危险因素。Objective To study the correlation of arterial elasticity with the levels of serum uric acid and blood lipid in middle and elderly male population.Methods A total of 279 male were enrolledand physical,biochemical and arterial elasticity tests were performed.Based on the pulse wave velocity(PWV),these were divided into two groups including non-arteriosclerosis group of 138 cases and arteriosclerosis group of 141 cases.Then we analyzed the correlation of arterial elasticity with serum uric acid and blood lipid levels.Results Compared with the non-arteriosclerosis control group,the serum levels of UA[(409.38±92.78)mmol/L VS.(433.84±93.43)mmol/L]and TG[(1.64±0.83)mmol/L VS.(2.26±1.37)mmol/L]were significantly elevated in arteriosclerosis group(P<0.05 or P<0.01),while there was no significant difference on the levels of LDL,HDL and TCh between the two groups.Pearson correlation analysis showed that there was a positive correlation of PWV with age,waist circumference and TG(r=0.169-0.439,P<0.05 or P<0.01).Conclusion TG,hyperuricemia,obesity,hypertension and abnormal blood glucose are risk factors for atherosclerosis in middle-aged and elderly men.

关 键 词：动脉硬化 尿酸 血脂 危险因素 

分 类 号：R194.3[医药卫生—卫生事业管理]