比较分析慢性阻塞性肺疾病患者与正常受试者中枢驱动水平  

Comparison of neural respiratory drive in COPD patients and healthy subjects

作　　者：林琳[1] 陈荣昌[1] LIN Lin;CHEN Rong-chang(Department of Respiratory Medicine,Guangzhou Institute of Respiratory Disease,Guangzhou,Guangdong　510000,China)

机构地区：[1]广州医科大学,广东广州510000

出　　处：《临床肺科杂志》2018年第5期825-828,共4页Journal of Clinical Pulmonary Medicine

摘　　要：目的比较正常受试者与慢阻肺患者的中枢驱动水平。方法选择2016年6-12月广州10名正常受试者与10名重度以上慢阻肺稳定期患者,利用经食道电极管检测静息状态下的中枢驱动水平,同时分析中枢驱动与肺功能的相关性。结果静息状态下,正常受试者与慢阻肺患者的中枢驱动分别为13.64±4.96%与57.26±15.45%(P<0.01),其与FEV_1%pred、FVC%pred、FEV_1/FVC(%)的相关系数分别为-0.842、-0.672、-0.716(P均<0.01)。结论慢阻肺患者中枢驱动水平明显高于正常受试者,且与患者肺功能呈明显负相关。Objective To compare neural respiratory drive(NRD)in COPD patients and healthy subjects.Methods Multipair oesophageal electrode catheter was used to measure the NRD in spontaneous breathing between COPD patients and healthy subjects,and the correlation coefficient of NRD with pulmonary function was analyzed.Results In spontaneous breathing,NRD of healthy subjects and COPD patients were 13.64±4.96%and 57.26±15.45%(P<0.01).Correlation coefficient of NRD with FEV 1%pred,FVC%pred,FEV 1/FVC(%)were-0.842,-0.672,and-0.716(all P<0.01)separately.Conclusion NRD in COPD patients is much higher than in healthy subjects,and it is negatively correlated with pulmonary function.

关 键 词：中枢驱动 慢阻肺 肌电图 

分 类 号：R563.9[医药卫生—呼吸系统]