参附对大鼠缺血再灌注心肌损伤炎症反应的影响  

Effect of Shenfu Injection on Inflammatory Response Following Myocardial Ischemia-Reperfusion Injury in Rats

作　　者：王琰康 唐昱[2] 刘燕锋[2] 祝志云[2] WANG Yan-kang;TANG Yu;LIU Yan-feng;ZHU Zhi-yun(Department of Cardiology,Yugan People’s Hospital,Yugan 333333,China;Department of Cardiology,Jiangxi Provincial People’s Hospital,Nanchang 330006,China)

机构地区：[1]余干县人民医院心内科,江西余干333333 [2]江西省人民医院心内科,南昌330006

出　　处：《南昌大学学报（医学版）》2018年第1期29-31,共3页Journal of Nanchang University：Medical Sciences

基　　金：江西省卫生厅中医药基金项目(2015A070)

摘　　要：目的探讨参附对大鼠心肌缺血再灌注损伤的炎症反应的影响。方法 30只健康SD大鼠随机分为假手术组(S组)、缺血再灌注组(I/R组)和参附组(SF组),每组10只。采用结扎左冠状动脉前降支的方法制备缺血再灌注模型。观察各实验组心肌组织病理形态变化,检测心肌组织匀浆中超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量。结果 1)I/R组心肌组织结构紊乱,可见局灶性坏死,明显炎性细胞浸润;与I/R组相比,SF组心肌损伤程度明显减轻,炎性病变显著减轻。2)与I/R组相比,SF组大鼠心肌组织匀浆中SOD活性升高,MDA水平降低。结论参附能够降低缺血再灌注心肌炎性反应,从而减轻心肌组织缺血再灌注损伤。Objective To investigate the effect of Shenfu injection on inflammatory response following myocardial ischemia-reperfusion injury in rats.Methods Thirty healthy SD rats were randomly divided into sham-operation group(S group),ischemia-reperfusion group(I/R group)and Shenfu injection group(SF group),with 10 rats in each group.The ischemia-reperfusion was induced by left anterior descending coronary artery ligation.Pathological changes,superoxide dismutase(SOD)activity and malondialdehyde(MDA)content in myocardial tissue were measured in all the three groups.Results Compared with S group,structural disorganization,focal necrosis and inflammatory cell infiltration were found in the myocardial tissue of I/R group.Compared with I/R group,myocardial injury,inflammatory lesion and MDA production were decreased and SOD activity was increased in SF group.Conclusion Shenfu injection can alleviate myocardial ischemia-reperfusion injury through reducing inflammatory response.

关 键 词：参附 心肌 缺血再灌注 动物 实验 大鼠 

分 类 号：R542.2[医药卫生—心血管疾病]