甲基多巴联合川芎嗪注射液对妊娠期高血压疾病患者血压改善及母婴结局的影响  

Effect of Methyldopa Combined with Ligustrazine Injection on the Improvement of Blood Pressure and Maternal and Neonatal Outcomes in Patients with Hypertensive Disorder Complicating Pregnancy

作　　者：王猛[1] 程晓利 WANG Meng;CHENG Xiao-li(Department of Obstetrics and Gynecology,Tanghe County People's Hospital,Nanyang Henan 473400,China;Department of Obstetrics and Gynecology,The First People`s Hospital of Luoyang,Luoyang Henan 471000,China)

机构地区：[1]河南省南阳市唐河县人民医院产科,河南南阳473400 [2]河南省洛阳市第一人民医院妇产科,河南洛阳471000

出　　处：《药品评价》2018年第7期55-57,共3页Drug Evaluation

摘　　要：目的:研究甲基多巴联合川芎嗪注射液对妊娠期高血压疾病患者血压改善及母婴结局的影响。方法:选取河南省南阳市唐河县人民医院2016年1月至2017年8月期间收治的妊娠期高血压疾病患者84例作为研究对象,按治疗方案不同分组,各42例。对照组给予川芎嗪注射液治疗,观察组给予甲基多巴+川芎嗪注射液治疗。比较两组治疗前后血压[收缩压(SBP)、平均动脉压(MAP)、舒张压(DBP)]水平、血浆黏度、24h蛋白尿定量及母婴结局。结果:治疗前,两组SBP、MAP、DBP、血浆黏度、24h蛋白尿定量比较,差异无统计学意义(P>0.05),治疗4周后,观察组SBP、MAP、DBP、血浆黏度、24h蛋白尿定量低于对照组,差异有统计学意义(P<0.05);观察组胎心异常率7.14%、剖宫产率16.67%、新生儿窒息率4.76%低于对照组28.57%、40.48%、23.81%,差异有统计学意义(P<0.05)。结论:甲基多巴联合川芎嗪注射液应用于妊娠期高血压疾病患者可降低血压水平,减少胎心异常、剖宫产、新生儿窒息等不良母婴结局。Objective:To investigate the effect of methyldopa combined with ligustrazine injection on improvement of blood pressure and maternal and neonatal outcomes in patients with hypertensive disorder complicating pregnancy.Methods:A total of 84 cases of hypertensive disorder complicating pregnancy in our hospital from January 2016 to August 2017 were selected as the research objects and divided into 2 groups according to different treatment schemes,with 42 cases in each group.The control group was treated with ligustrazine injection,and the observation group was treated with methyldopa and ligustrazine injection.The blood pressure levels[systolic blood pressure(SBP),mean arterial pressure(MAP),diastolic blood pressure(DBP)],plasma viscosity,24 h-proteinuria,and maternal and neonatal outcomes were compared between the two groups before and after treatment.Results:Before treatment,there was insignificant difference in SBP,MAP,DBP,plasma viscosity and 24 h urine protein between the two groups(P>0.05).After 4 weeks of treatment,the SBP,MAP,DBP,plasma viscosity and 24 h-proteinuria in the observation group were lower than those in the control group(P<0.05).The abnormal rate of fetal heart,cesarean section rate and neonatal asphyxia rate of the observation group were 7.14%,4.76%and 28.57%,which were lower than those of the control group 28.57%,40.48%and 23.81%(P<0.05).Conclusion:Methyldopa combined with ligustrazine injection in patients with hypertensive disorder complicating pregnancy can reduce the blood pressure level,reduce the fetal heart abnormalities,cesarean section,neonatal asphyxia and other adverse maternal and child outcomes.

关 键 词：妊娠期高血压疾病 川芎嗪注射液 甲基多巴 血压 母婴结局 

分 类 号：R271.41[医药卫生—中医妇科学]