25-(OH)D3、NT-proBNP、PCT在评价冠心病患者病情及近期预后的临床应用  

Clinical application of 25-(OH)D3,NT-proBNP and PCT in evaluating the condition and short-term prognosis of coronary heart disease

作　　者：杨红亮[1] 孟利敏[1] 鞠阳[1] Yang Hongliang;Meng Limin;Ju Yang(Department of Internal medicine,The Handan area of Jizhong Energy Fengfeng Group General Hospital)

机构地区：[1]冀中能源峰峰集团总医院邯郸院区内科,邯郸056001

出　　处：《中国循证心血管医学杂志》2018年第3期337-339,共3页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的探讨患者血清25羟维生素D3[25-(OH)D3]、血清降钙素原(PCT)、N端脑钠肽前体(NT-pro BNP)水平在判断冠状动脉粥样硬化性心脏病(冠心病,CAD)病情及近期预后的临床应用价值。方法选取2015年1月~2016年12月于冀中能源峰峰集团总医院邯郸院区就诊的156例冠心病患者,随访3个月,以是否死亡将病例组分为非死亡组和死亡组,其中死亡组16例,平均年龄63.5±1.5岁,非死亡组140例,平均年龄62.8±2.2岁。测定患者入院时血清25-(OH)D3、NT-pro BNP、PCT、血脂水平;心脏超声及冠状动脉造影结果,冠状动脉病变Gensini评分。同时选取同时期本院进行健康体检的80例志愿者,测定血清25-(OH)D3、NT-pro BNP、PCT、血脂水平、心脏超声等体检资料作对照组。结果与对照组比较,病例组高密度脂蛋白胆固醇(HDL-C)明显降低(P<0.05);胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平明显升高(P<0.05)。病例组血清25-(OH)D3明显降低(P<0.05);NT-pro BNP、PCT水平明显高于对照组(P<0.05)。非死亡组HDL-C水平明显高于死亡组,TC、TG、LDL-C水平明显低于死亡组(P<0.05)。与对照组比较,病例组LVEF明显降低(P<0.05);而LVEDD、LVESD明显增高(P<0.05)。与非死亡组比较,死亡组LVEF明显降低(P<0.05);而LVEDD、LVESD、Gensini评分明显增高(P<0.05)。非死亡组血清25-(OH)D3水平明显高于死亡组,NT-pro BNP、PCT水平明显低于死亡组(P<0.05)。结论检测血清25-(OH)D3、BNP、PCT水平对于评估冠心病患者病情严重程度及预后具有一定的临床价值。Objective To investigate clinical value of the serum 25-hydroxyvitamin D3[25-(OH)D3],procalcitonin(PCT),N-terminal pro-B-type natriuretic peptide(NT-proBNP)in evaluating coronary artery disease(CAD)condition and recent prognosis.Methods 156 coronary heart disease patients enrolled as case group from 2015.01 to 2016.12 were divided into improved group and death group after three months follow-up.There were 16 patients in the death group;the average age was 63.5±1.5 years.There were 140 patients in the improved group;the average age was 62.8±2.2 years.80 healthy volunteers were enrolled as the control group.Results Compared with the control group,the serum levels of 25-(OH)D3 and HDL-C were significantly lower in the case group.The levels of NT-proBNP,PCT,TC,TG and LDL-C were significantly of case group were higher than those of the control group.The levels of serum 25-(OH)D3 and HDL-C in the improved group were significantly higher than those in the death group.The levels of NT-proBNP,PCT,TC,TG and LDL-C were significantly lower than those in the death group.Compared with the control group,the LVEF in the case group decreased significantly,while the LVEDD and LVESD increased significantly.Compared with the improvement group,the death group LVEF decreased significantly,while the scores of LVEDD,LVESD and Gensini increased significantly.Conclusion The detection of serum 25-(OH)D3,BNP and PCT levels has clinical value in assessing the severity and prognosis of patients with coronary heart disease.

关 键 词：25羟维生素D3 降钙素原 N端脑钠肽前体 冠心病 

分 类 号：R541[医药卫生—心血管疾病]