脑脊液蛋白含量变化与吉兰巴雷综合征治疗方案的相关性研究  

Study on the relationship between the treatments of Guillain-Barre syndrome and changes of protein content in the cerebrospinal fluid

作　　者：梅育嘉[1] 罗杰峰[1] 许红玉 

机构地区：[1]广西医科大学第二附属医院,广西南宁530003 [2]广西民族医院,广西南宁530001

出　　处：《大众科技》2018年第3期46-47,41,共3页Popular Science & Technology

摘　　要：目的:用脑脊液蛋白含量变化作为吉兰巴雷综合征(Guillain-Barre syndrome,GBS)治疗效果的观察指标,评价治疗方案的有效性及安全性。方法:对63例广西医科大学第二附属医院住院的存在明显肌力障碍的GBS患者,用治疗前后2次脑脊液蛋白含量商作为治疗观察指标,作多因素相关分析,判断治疗方案的有效性及安全性。结果:年龄、前驱感染、血浆置换、激素冲击与蛋白商显著独立相关(P<0.05),其中血浆置换呈正相关,对治疗有效;激素冲击呈负相关,提示可能对GBS患者不利。结论:脑脊液蛋白含量变化是GBS疗效评价的良好指标。Objective:To evaluate the efficacy and safety of the treatments of Guillain-Barre syndrome by analyzing the changes of protein content after the treatments.Methods:Data of 63 patients with GBS admitted to our hospital were collected,calculate the data of first protein content in the cerebrospinal fluid divided by the second one’s,and make an analysis of it with the data of patients including the treatments by logistic regression.Results:Age,prodromal infection,plasma exchange and Glucocorticoid pulse therapy are significantly correlated with protein quotient(P<0.05),plasma exchange is positively correlated,effective for treatment,glucocorticoid pulse therapy is negatively correlated,might be unfavorable for GBS patients.Conclusion:The changes of protein content in the cerebrospinal fluid is an effective indicator for evaluation of curative effect in GBS patient.

关 键 词：脑脊液蛋白 激素 血浆置换 

分 类 号：R593[医药卫生—内科学]