血清纤维连接蛋白检测对肥胖孕妇罹患先兆子痫风险的研究  

Study on the Risk of Preeclampsia in Obese Pregnant Women with Serum Fibronectin

作　　者：刘苗 杨丽欣 LIU Miao;YANG Li-xin(Zhao Country People's Hospital,Hebei 051530)

机构地区：[1]河北省石家庄市赵县人民医院妇二科,051530

出　　处：《临床输血与检验》2018年第2期157-159,共3页Journal of Clinical Transfusion and Laboratory Medicine

基　　金：石家庄科技局课题(No.161462673)资助

摘　　要：目的观察血清纤维连接蛋白(FN)检测对肥胖孕妇罹患先兆子痫风险的预测价值。方法 2016年1月~2017年5月,选择在河北省赵县人民医院行孕期保健的孕妇120例,其中60例为正常孕妇,血压正常且未见先兆子痫,包括正常体重孕妇(A组)与肥胖孕妇(B组)各30例;另60例为先兆子痫孕妇,包括正常体重孕妇(C组)与肥胖孕妇(D组)各30例,检测上述4组孕妇血清FN水平,并对比先兆子痫与非先兆子痫孕妇的妊娠结局。结果与A组比较,B组孕妇的体重指数(BMI)、平均动脉压(mean artery pressure,MAP)、血清FN水平明显升高(P<0.05);与C组比较,D组孕妇的BMI明显升高(P<0.05),但MAP、血清FN水平对比差异无统计学意义(P>0.05);与A、B组比较,C、D组孕妇的血清FN水平明显升高,且D组明显高于C组(P<0.05);与先兆子痫孕妇比较,非先兆子痫孕妇的剖宫产率,新生儿Apgar评分,胎儿窘迫、早产、胎儿宫内生长迟缓发生率均明显降低(P<0.05),但分娩孕周及死胎死产对比差异无统计学意义(P>0.05)。结论检测血清FN水平对肥胖孕妇罹患先兆子痫风险有一定预测价值,且先兆子痫孕妇妊娠结局更差。Objective To investigate the predictive value of serum fibronectin(FN)in the risk of preeclampsia in obese pregnant women.Methods From January 2016 to May 2017,120 cases for health care during pregnancy pregnant women were selected in Hebei province people's Hospital,60 cases of normal pregnant women with normal blood pressure and no pre eclampsia,including pregnant women of normal weight(A group)and obese pregnant women(B group)each 30 cases;another 60 cases of pregnant women with preeclampsia,including pregnant women of normal weight(C group)and obese pregnant women(D group)each 30 cases,the serum FN levels were detected in pregnant women of four groups,and the outcome of pregnancy in patients with preeclampsia and pre eclampsia was compared.Results Compared with A group,the BMI,MAP,serum FN level of B group increased significantly(P<0.05);Compared with C group,the BMI of D group increased significantly(P<0.05),but MAP,serum level of FN was no statistical significance(P>0.05);Compared with A and B group,the serum level of FN in C and D group significantly increased,and the D group was significantly higher than that of C group(P<0.05);Compared with pre eclampsia,the cesarean section rate,neonatal Apgar score,fetal distress,premature delivery,intrauterine growth retardation were significantly reduced in no-preeclampsia pregnant women(P<0.05),but there were no statistical significance in gestational age of delivery and stillbirth between above two groups(P>0.05).Conclusion The detection of serum FN level has some predictive value for the risk of pre eclampsia in pregnant women with obesity,and worse pregnancy outcome of preeclampsia.

关 键 词：血清纤维连接蛋白 孕妇/肥胖 先兆子痫 发生风险 

分 类 号：R446.11[医药卫生—诊断学] R714.244[医药卫生—临床医学]