可控微波促进水溶液中羟基芳甲酸与氯化苄的选择性反应  

Selective Reaction of Hydroxyaromatic Acid with Benzyl Chloride in Water Using Controlled Microwave Heating

作　　者：白林[1] 王晓娟 田应凤 刘振国 杨茹霞 BAI Lin;WANG Xiao-juan;TIAN Ying-feng;LIU Zhen-guo;YANG Ru-xia(Institute of Green Chemistry Experiment and Teaching,Lanzhou City University,Lanzhou 730070,China)

机构地区：[1]兰州城市学院绿色化学实验与教学研究所,甘肃兰州730070

出　　处：《兰州文理学院学报（自然科学版）》2018年第2期53-57,共5页Journal of Lanzhou University of Arts and Science(Natural Sciences)

摘　　要：以水为溶剂,在相转移催化剂和微波加热的协同作用下,羟基芳甲酸和氯化苄同时发生酯化反应和醚化反应,"一锅"法高效地合成了15种苄氧基芳甲酸苄酯类化合物.通过原料比、微波辐射时间、温度、催化剂和碱的种类优化出最佳合成条件.在微波筛选条件的基础上,采用常规放大实验,合成了相应的克级产品.产物结构通过熔点测定、IR和~1HNMR谱分析确定.The simultaneous esterification and etherification of hydroxyaromatic acid and benzyl chloride were carried out in the synergy of phase transfer catalysis,microwave heating and water as solvent.15 kinds of compounds were synthesized by one-pot method in excellent yields.The reaction conditions were optimized by the ratio of raw materials,time and temperature of microwave radiation,the type of catalyst and the bases.On the basis of microwave screening conditions,the conventional amplification experiment was used to synthesize the corresponding products with a good yield in grams scale.The structure of the product was characterized by the melting point,infrared and hydrogen nuclear magnetic resonance spectrum.

关 键 词：羟基芳甲酸 双官能团化反应 水溶液 相转移催化剂 微波加热 环境友好合成 

分 类 号：O621.3[理学—有机化学]