磁共振弥散张量成像在急性期弥漫性轴索损伤诊断中的应用价值  

The Value of DTI in Diagnosis of Diffuse Axonal Injury in the Acute Phase

作　　者：赵如盛 张娇娇 ZHAO Ru-sheng;ZHANG Jiao-jiao(Department of Radiology,the First Affiliated Hospital to Nanjing Medical University,Nanjing,Jiangsu Province,210029 China;Department of Radiology,Children’s Hospital Affiliated to Nanjing Medical University,Nanjing,Jiangsu Province,210008 China)

机构地区：[1]南京医科大学第一附属医院放射科,江苏南京210029 [2]南京医科大学附属儿童医院放射科,江苏南京210008

出　　处：《中外医疗》2018年第3期3-5,8,共4页China & Foreign Medical Treatment

摘　　要：目的研究磁共振弥散张量成像(diffusion tensor imaging DTI)在诊断急性期弥漫性轴索损伤中的应用价值。方法方便筛选2016年1月—2017年1月南京医科大学第一附属医院收治的弥漫型轴索损害急性期(Diffuseatonalinjury DAI)患者50例作为研讨目标,另挑选正常人员40名作为对照组。结果 (1)急性期DAI患者胼胝体压部FA值为(0.51±0.05),胼胝体膝部FA值(0.69±0.06),内囊后肢FA值为(0.66±0.02)、大脑脚FA数值为(0.60±0.04),急性DAI患者的胼胝体压部、膝部、内囊后肢、大脑脚感兴趣区的FA值与健康对照组对应区域的FA值对比存在明显区别,差异有统计学意义(P<0.05);但急性期DAI患者胼胝体体部、内囊前肢FA目标与健康对照组对应区域的FA目标对比无明显区别,差异无统计学意义(P>0.05)。(2)急性期DAI患者胼胝体压部RA值为(0.55±0.01),胼胝体体部RA值(0.60±0.03),内囊后肢RA值为(0.50±0.05)、大脑脚RA数值为(0.49±0.03),急性DAI患者的胼胝体压部、体部、内囊后肢、大脑脚感兴趣区的RA值与健康对照组对应区域的RA值比较存在显著区别,差异有统计学意义(P<0.05)。(3)急性期DAI患者胼胝体压部ADC值为(0.74±0.07),内囊后肢ADC值为(0.66±0.03),急性期DAI患者胼胝体压部、内囊后肢ADC指标与健康对照组对应区域的ADC值比较存在显著区别,差异有统计学意义(P<0.05)。结论对于急性期弥漫性轴索损害患者行DTI序列可见患者脑深部白质纤维束FA、RA、ADC值明显反常,据此剖析可知DTI依据患者脑深部各感兴趣区域FA、RA、ADC数值判别急性弥漫性轴索损害患者的反常弥散性改动,能够显著提高DAI的检出率与确诊能力。Objective This paper tries to evaluate the value of magnetic resonance diffusion tensor imaging in the diagnosis of diffuse axonal injury in acute phase.Methods 50 patients with diffuse axonal injury(Diffuse atonal injury DAI)in this hospital from January 2016 and January 2017 were conveient selected as the research objects,and 40 normal persons were selected as the control group.Results①For acute DAI patients,the splenium FA value was(0.51±0.05),corpus callosum FA value(0.69±0.06),FA value of the posterior limb of the internal capsule(0.66±0.02),cerebral peduncle FA value(0.60±0.04),corpus callosum,genu and splenium posterior limb of internal capsule,cerebral peduncle region of interest FA value comparison has the obvious difference from the healthy control group of the corresponding region FA,with statistical difference(P<0.05);but in the acute phase of DAI patients of corpus callosum,anterior limb of the FA target and FA target group compared to healthy controls showed no significant difference between the corresponding region,without statistical significance(P>0.05).②Acute DAI patients of splenium RA value was(0.55±0.01),corpus callosum RA value(0.60±0.03),RA value of the posterior limb of the internal capsule(0.50±0.05),cerebral peduncle RA numerical(0.49±0.03),corpus callosum splenium,body department,posterior limb of internal capsule,cerebral peduncle region of interest RA values compared with control group,there were significant differences,corresponding to the RA values of,with statistical significance(P<0.05).③DAI patients with corpus callosum ADC value was(0.74±0.07),ADC value of the posterior limb of the internal capsule(0.66±0.03),DAI patients with corpus callosum,posterior limb of the internal capsule ADC index compared with control group there were significant differences,corresponding to the ADC values of,with statistical significance(P<0.05).Conclusion For acute stage patients with diffuse atonal injury patients DTI view visible deep brain white matter fiber tracts FA,RA,ADC value

关 键 词：磁共振弥散张量成像 弥漫性轴索损伤 诊断 

分 类 号：R445[医药卫生—影像医学与核医学]