乳腺癌手术前后,cd44+/cd24-,aldh1+作为人乳腺癌肿瘤干细胞标志物血浆细胞含量变化与临床相关性分析  

Analysis of Correlation between the Plasma Cell Content Changes and Human Breast Cancer Tumor Stem Cell Marker Using cd44+/cd24-,aldh1+ before and after Breast Cancer Surgery

作　　者：徐延森 马红艳 杨明月 王平 李秀清 鞠英博 孙杰 杜文雅 XU Yan-sen;MA Hong-yan;YANG Ming-yue;WANG Ping;LI Xiu-qing;JU Ying-bo;SUN Jie;DU Wen-ya(Department of Hepatobiliary and Pancreatic Minimally Invasive Surgery,Cangzhou People’s Hospital,Cangzhou,Hebei Province,061001 China;Department of Pathology,Cangzhou People’s Hospital,Cangzhou,Hebei Province,061001 China)

机构地区：[1]河北省沧州市人民医院肝胆胰微创外科,河北沧州061001 [2]河北省沧州市人民医院病理科,河北沧州061001

出　　处：《中外医疗》2018年第2期19-20,23,共3页China & Foreign Medical Treatment

摘　　要：目的观察正常人,乳腺癌患者手术前后cd44+/cd24-,aldh1+作为人乳腺癌肿瘤干细胞标志物血浆细胞变化情况,分析其与乳腺癌的临床相关性。方法方便选取该院30名健康医护人员以及自2016年1月—2017年6月收治的30例乳腺癌患者作为该次研究对象,检测健康人员与乳腺癌患者手术前后的cd44+/cd24-,并将aldh1+作为人乳腺癌肿瘤干细胞标志物血浆细胞含量,分析数据。结果健康人员与乳腺癌患者的aldh1+作为人乳腺癌肿瘤干细胞标志物,两组人员的血浆细胞含量差异无统计学意义(P>0.05),采用乳腺癌外周血中的cd44+/cd24-作为人乳腺癌肿瘤干细胞标志物时,乳腺癌患者的血浆细胞含量(5.3±2.1)%明显高于健康人组(0.0±0.0)%,两组对比差异有统计学意义(P<0.05),且手术后,乳腺癌患者cd44+/cd24-,aldh1+作为人乳腺癌肿瘤干细胞标志物血浆细胞含量均有降低,手术后cd44+/cd24-作为人乳腺癌肿瘤干细胞标志物血浆细胞含量(0.7±0.3)%明显小于手术前(5.3±2.1)%,手术后aldh1+作为人乳腺癌肿瘤干细胞标志物血浆细胞含量(0.8±0.3)%明显小于手术前(3.7±1.2)%,各组数据对比均差异有统计学意义(P<0.05)。结论 cd44+/cd24-,aldh1+作为人乳腺癌肿瘤干细胞标志物血浆细胞含量与乳腺癌疾病的发生和发展具有正相关关系。Objective To observe the correlation between the Plasma cell content changes and human breast cancer tumor stem cell marker using cd44+/cd24-,aldh1+before and after breast cancer surgery.Methods 30 cases of healthy medical staff in our department and 30 cases of breast cancer patients admitted and treated in our hospital from January 2016 to June 2017 were conveniently selected as the research objects and the cd44+/cd24-of healthy staff and breast cancer patients before and after surgery was tested and the aldh1+was used as the plasma cell content of the human breast cancer tumor stem cell marker,and the data were analyzed.Results There was no obvious difference in the plasma cell content between the two groups(P>0.05),and the cd44+/cd24-was used as the human breast cancer tumor stem cell marker in the peripheral blood of breast cancer,and the plasma cell content of the breast cancer patients was obviously higher than that of healthy group,[(5.3±2.1)%vs(0.0±0.0)%],and the difference was obvious(P<0.05),after surgery,the cd44+/cd24-,aldh1+of breast cancer patients decreased,and the content of cd44+/cd24-after surgery was obviously lower than that before surgery,[(0.7±0.3)%vs(5.3±2.1)%],after surgery,the aldh1+was obviously lower than that before surgery[(0.8±0.3)%vs(3.7±1.2)%],and the difference was statistically significant(P<0.05).Conclusion The cd44+/cd24-,aldh1+as the human breast cancer tumor stem cell marker plasma cell content is positively correlated with the occurrence and development of breast cancer.

关 键 词：乳腺癌手术 cd44+/cd24- aldh1+ 血浆含量 临床相关性 

分 类 号：R5[医药卫生—内科学]