血液肿瘤儿童合并可逆性后部脑病综合征2例并文献复习  

Literature review and 2 cases of children with posterior reversible encephalopathy syndrome and hematological neoplasm

作　　者：宋庆红 李学荣[1] 仲任[1] 姜健[1] SONG Qing-hong;LI Xue-rong;ZHONG Ren;JIANG Jian(Pediatric Hematology Department,the Affiliated Hospital of Qingdao University,Qingdao 266000,China)

机构地区：[1]青岛大学附属医院血液儿科,山东青岛266000

出　　处：《临床医学研究与实践》2018年第11期74-76,共3页Clinical Research and Practice

摘　　要：目的通过分析儿童血液肿瘤合并可逆性后部脑病综合征(PRES)的临床特征、影像学特点、治疗及预后,提高儿科医生对儿童血液肿瘤合并PRES的认识。方法回顾性分析本院小儿血液科收治的血液肿瘤合并PRES患儿2例,并复习相关文献资料。结果经过积极控制血压、脱水降颅内压、止惊等治疗,2例患儿症状完全缓解,病例一影像学检查显示脑内异常信号明显吸收好转,病例二因经济原因未按医嘱执行颅脑MR。结论血液肿瘤患儿在应用大剂量药物化疗及免疫抑制剂治疗期间可能合并PRES,存在的高血压或许是使动因素;颅脑影像学检查,尤其颅脑MRI是诊断该病的主要依据。Objective To analyse the clinical characteristics,imaging features,treatment and prognosis of hematological neoplasm in children with posterior reversible encephalopathy syndrome(PRES),so as to improve the pediatrician understanding of children with hematological neoplasm with PRES.Methods A retrospective analysis of 2 children with PRES in pediatric hematology department of our hospital was reviewed,and the related literature was reviewed.Results After active control of blood pressure,dehydration intracranial pressure and stopping convulsion treatment,2 cases completely relieved.The imaging examination of case one showed that abnormal signal absorption improved in the brain.Case two did not perform brain MR according to the doctor's advice because of economic reasons.Conclusion Children with hematological neoplasm treated with high-dose chemotherapy and immunosuppressive therapy may complicate with PRES.The presence of hypertension may be a driving factor.Cranial imaging examination,especially cranial MRI is the main basis of diagnose of this disease.

关 键 词：血液肿瘤疾病 可逆性后部脑病综合征 血压 

分 类 号：R725[医药卫生—儿科]