痰湿型多囊卵巢综合征患者临床特征分析  

Clinical characteristics analysis of polycystic ovary syndrome with syndrome of phlegm dampness

作　　者：徐芳[1] 侯丽辉[1] 刘颖华 王梦思[1] 丁春丽 牛静云 XU Fang;HOU Lihui;LIU Yinghua;WANG Mengsi;DING Chunli;NIU Jingyun(Department of Gynaecology and Obstetrics,the First Affiliated Hospital,Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin 150040,China;Department of Gynaecology and Obstetrics,the Affiliated Hospital of Liaoning University of TCM,Liaoning Province,Shenyang 110023,China)

机构地区：[1]黑龙江中医药大学附属第一医院妇产科,黑龙江哈尔滨150040 [2]辽宁中医药大学附属医院妇产科,辽宁沈阳110023

出　　处：《中国医药导报》2018年第9期118-122,共5页China Medical Herald

基　　金：黑龙江省中医药管理局项目(ZHY16-029)

摘　　要：目的探讨痰湿证多囊卵巢综合征(PCOS)患者的临床特征、性激素及糖脂代谢特征。方法回顾性分析2013年9月~2015年8月黑龙江中医药大学附属第一医院临床科研信息一体化系统PCOS妇科门诊病例资料。按照痰湿证的诊断标准,将PCOS患者分为痰湿证和非痰湿证。比较分析患者的临床特征、性激素及糖脂代谢异常情况。结果共纳入617例PCOS患者,其中痰湿型PCOS患者393例(63.7%),非痰湿型PCOS患者224例(36.3%)。痰湿型PCOS组体重指数、腰臀比、收缩压、舒张压、黑棘皮发生率、溢脂发生率、胰岛素抵抗发生率、空腹糖耐量受损发生率、睾酮、空腹血糖、空腹胰岛素、稳态模型胰岛素抵抗指数、总胆固醇、三酰甘油、低密度脂蛋白胆固醇、总胆固醇/高密度脂蛋白胆固醇、三酰甘油/高密度脂蛋白胆固醇、低密度脂蛋白胆固醇/高密度脂蛋白胆固醇、脂质蓄积指数水平显著高于非痰湿型PCOS组(P<0.05)。痰湿型PCOS组多毛发生率、黄体生成素、促卵泡激素、黄体生成素/促卵泡激素、性激素结合球蛋白、高密度脂蛋白胆固醇水平显著低于非痰湿型PCOS组(P<0.05)。结论痰湿证型是PCOS患者的主要证型之一;痰湿型PCOS患者存在明显的性激素和糖脂代谢异常,胰岛素抵抗是痰湿型PCOS的重要代谢特征。Objective To investigate the clinical characteristics,sex hormones and glucose and lipid metabolism characteristics of PCOS patients with syndrome of phlegm dampness.Methods From September 2013 to August 2015,the data of gynecological outpatient patients with PCOS from Clinical Research Information Integration System of First Affiliated Hospital,Heilongjiang University of Chinese Medicine were analyzed retrospectively.All the patients were divided into two groups according to the diagnostic criteria of PCOS with syndrome of phlegm dampness.The clinical characteristics,sex hormones and abnormal metabolism of glucose and lipid were compared and analyzed.Results Among 617 cases of PCOS,393 cases(63.7%)were PCOS with syndrome of phlegm dampness,and 224 cases(36.3%)were non phlegm dampness.The body mass index,waist hip ratio,systolic blood pressure,diastolic blood pressure,incidence of acanthosis,excessive fat,insulin resistance,impaired glucose tolerance,testosterone,fasting blood glucose,fasting insulin,insulin resistance index,total cholesterol,triglyceride,low density lipoprotein cholesterol,total cholesterol high density lipoprotein,triglyceride/high density lipoprotein cholesterol,low density lipoprotein cholesterol/high density lipoprotein cholesterol and lipid accumulation index in the phlegm dampness syndrome PCOS group were higher than those in non phlegm dampness syndrome PCOS group(P<0.05).The hairy incidence,luteinizing hormone,follicle stimulating hormone,luteinizing hormone/follicle stimulating hormone,sex hormone binding globulin,high density lipoprotein cholesterol levels in phlegm dampness PCOS group were lower than those in the non phlegm dampness syndrome PCOS group(P<0.05).Conclusion Phlegm dampness syndrome is one of the main syndromes of PCOS patients;PCOS patients with syndrome of phlegm dampness have obvious sex hormones and glucose and lipid metabolism abnormality.Besides insulin resistance is an important metabolic characteristic of PCOS with syndrome of phlegm dampness.

关 键 词：多囊卵巢综合征 痰湿证 临床特征 

分 类 号：R711.75[医药卫生—妇产科学]