甲泼尼龙致急性类固醇肌病伴肝损伤1例的分析  

Analysis of Methylprednisolone-induced Acute Steroid Myopathy with Hepatic Injury

作　　者：洪敏 刘晓玲[2] 邢刚[1] HONG Ming;LIU Xiao-ling;XING Gang(Department of ICU,Xuzhou Central Hospital,Xuzhou 221009;Department of Pharmacy,Xuzhou Central Hospital,Xuzhou 221009)

机构地区：[1]徐州市中心医院ICU,徐州221009 [2]徐州市中心医院药学部,徐州221009

出　　处：《药学与临床研究》2018年第2期139-140,共2页Pharmaceutical and Clinical Research

摘　　要：一例43岁男性因患吉兰-巴雷综合征,应用大剂量甲泼尼龙(1000 mg·d-1)静脉冲击治疗,在激素逐渐减量至60 mg的第10天,患者出现了酱油色尿及肌酸激酶(CK)、乳酸脱氢酶(LDH)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)急剧升高,诊断为急性类固醇肌病伴肝损伤。予以停用甲泼尼龙,碱化尿液,对症支持治疗。停用甲泼尼龙的第11天,患者ALT、AST显著下降,CK及肌红蛋白(Mb)基本恢复正常。A 43-year-old man was treated with high-dose methylprednisolone(1000 mg·day-1)for Guillain-Barre syndrome.On the tenth day when the hormone was gradually reduced to 60 mg,the patient developed soy sauce urine and dramatically increased blood creatine kinase,lactate dehydrogenase,ALT and AST,considered as acute steroid myopathy with heptatic injury.On the 11th day after the stop of methylprednisolone with alkalized urine and the symptomatic and supportive treatments,the patients’ALT and AST levels decreased significantly,and the serum creatine kinase and myoglobin returned to normal.

关 键 词：类固醇肌病 不良反应 甲泼尼龙 

分 类 号：R969.3[医药卫生—药理学]