血浆D-二聚体浓度与2型糖尿病肾损害的相关性分析  

Correlation analysis of plasma D-dimer concentration and renal damage in type 2 diabetes

作　　者：马翼[1] MA Yi(Department of Laboratory of Huamu Community Health Service Center of Pudong New District,Shanghai 201204,China)

机构地区：[1]上海市浦东新区花木社区卫生服务中心检验科,上海201204

出　　处：《上海医药》2018年第8期35-37,共3页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的 :探讨2型糖尿病(T2DM)患者D-二聚体浓度与肾损害的相关性。方法 :收集2015年1月至2016年2月门诊收治的T2DM患者93例,按血浆D-二聚体浓度分为正常组48例和升高组45例,并收集45名体检合格者作为健康组。检测所有受试者的血浆D-二聚体浓度、尿白蛋白(Alb)浓度、肌酐浓度、尿白蛋白/肌酐(Alb/Cr)值、尿N-乙酰-β-D氨基葡萄糖酶(NAG)和肾小球滤过率(eGFR)。结果 :正常组、升高组和健康组的血浆D-二聚体浓度分别为(0.34)mg/ml、(1.10)mg/ml和(0.28)mg/ml,正常组和健康组间差异无统计学意义(P>0.05),但升高组与正常组和健康组间差异有统计学意义(P<0.05)。升高组与正常组和健康组的Alb/Cr、eGFR和NAG差异均有统计学意义(P<0.01)。T2DM患者血浆D-二聚体浓度与Alb/Cr和NAG呈显著正相关(P<0.01),与eGFR呈显著负相关(P<0.01)。结论 :血浆D-二聚体浓度与T2DM肾微血管、肾小球、肾小管损害关系密切,监测并调控D-二聚体浓度有助于糖尿病肾病的防治。Objective:To investigate the correlation between the concentration of D-dimer and renal damage in patients with type 2 diabetes mellitus(T2DM).Methods:Ninty-three cases of T2DM patients admitted from January 2015 to February 2016 were collected and according to the concentration of plasma D-dimer they were divided into a normal group with 48 cases and an elevated group with 45 cases,and 45 qualified persons of physical examination were collected as the health group.Plasma D-dimer concentration,urinary albumin(Alb)concentration,creatinine concentration,urinary albumin/creatinine(Alb/Cr)value,urine N-acetylacetyl beta glucosaminidase(NAG)and glomerular filtration rate(eGFR)were detected in all subjects.Results:The concentration of plasma D-dimer in the normal group,the elevated group and the healthy group were(0.34)mg/ml,(1.10)mg/ml and(0.28)mg/ml,respectively,and there was no significant difference between the normal group and the healthy group(P>0.05).However,there was a significant difference between the elevated group and the normal group and the healthy group(P<0.05).The difference of Alb/Cr,eGFR and NAG between the elevated group and the normal group and the healthy group were statistically significant(P<0.01).The concentration of D-dimer in plasma of T2DM patients was significantly positively correlated with Alb/Cr and NAG(P<0.01),and had a significant negative correlation with eGFR(P<0.01).Conclusion:The concentration of plasma D-dimer is closely related to T2DM renal microvascular,glomeruli and renal tubule damage.Monitoring and regulating the concentration of D-dimer is helpful for the prevention and treatment of diabetic nephropathy.

关 键 词：2型糖尿病 D-二聚体 糖尿病肾病 

分 类 号：R587.2[医药卫生—内分泌]