3-甲氧基氯苄的制备方法研究  

Study on Preparation of 3-Methoxyl Chloride

作　　者：汪继根 朱红薇[1] 康李伟 乔晋文 钱广[1] WANG Ji-gen;ZHU Hong-wei;KANG Li-wei;QIAO Jin-wen;QIAN Guang(College of Biology and Chemical Engineering,Jiaxing University,Zhejiang Jiaxing 314001,China)

机构地区：[1]嘉兴学院生物与化学工程学院,浙江嘉兴314001

出　　处：《广州化工》2018年第7期39-41,共3页GuangZhou Chemical Industry

基　　金：2017年嘉兴学院校级重点SRT项目(编号:85171777)

摘　　要：以3-甲氧基苯甲酸为原料,将3-甲氧基苯甲酸与甲醇在浓硫酸催化下酯化合成3-甲氧基苯甲酸甲酯,然后在60~65℃下,将合成的3-甲氧基苯甲酸甲酯经硼氢化钠还原得到3-甲氧基苯甲醇,最后3-甲氧基苯甲醇在吡啶催化下以氯化亚砜作为卤化剂,卤化合成3-甲氧基氯苄,总收率为72%,效果较好。本法操作简单,实验条件要求低,原料易得廉价,适合工业化生产,此外,还探究了羧酸酯还原成相应醇的实验中影响产率的相关条件,具有一定价值。Taking 3-methoxy benzoic acid as raw material,methyl 3-methoxybenzoate was synthesized by the esterification reaction of 3-methoxybenzoic acid and methanol under the catalysis of concentrated sulfuric acid.At 60~65℃,the synthesized 3-methoxybenzoate was reduced by sodium borohydride to obtain 3-methoxybenzyl alcohol.Using pyridine as a catalyst,thionyl chloride as a halogenating agent,3-methoxybenzyl alcohol was synthesized to 3-methoxybenzyl chloride by halogenation.The total yield was 72%and the effect was better.This method was simple,experimental conditions were low and raw materials were cheap and easy to get.It was suitable for industrial production.In addition,the carboxylate ester reduction to the corresponding alcohol experiment conditions affected the yield of the relevant conditions was also explored,which had some scientific value.

关 键 词：3-甲氧基苯甲酸 3-甲氧基苯甲酸甲酯 3-甲氧基苯甲醇 3-甲氧基氯苄 

分 类 号：O625[理学—有机化学]