苯佐卡因衍生物的合成  

Synthesis of Benzocaine Derivative

作　　者：李文丽[1] 赵杰[1] 崔玉洁 LI Wenli;ZHAO Jie;CUI Yujie(Chongqing Energy College,Petroleum Chemical Testing Center,Chongqing 402260,China;Depp Medical Technology Chemical Co.Ltd.,Jinan 250000,China)

机构地区：[1]重庆能源职业学院石油化工检测中心,重庆402260 [2]德普顿斯医药技术有限公司,山东济南250000

出　　处：《化工技术与开发》2018年第2期15-17,共3页Technology & Development of Chemical Industry

基　　金：重庆市教委科学技术研究项目(KJ1505501)

摘　　要：以对硝基甲苯为原料,分别经氧化、酯化和还原反应合成苯佐卡因,苯佐卡因再与1-溴丁烷进行N-烷基化反应,合成苯佐卡因衍生物4-(正丁基氨基)苯甲酸乙酯。采用FTIR、1HNMR确认其结构,并研究其反应条件。结果表明,合成苯佐卡因衍生物4-(正丁基氨基)苯甲酸乙酯的最佳条件为:反应温度60℃,反应时间0.5h,原料的摩尔比苯佐卡因∶1-溴丁烷=1∶4.6。Benzocaine derivative ethyl 4-(butylamino)benzoate was synthesized by reaction of 1-bromobutane and benzocaine.The benzocaine was synthesized by oxidization,esterification and reducing reaction from p-nitrotoluene.The structure of the object was confirmed by FTIR,1HNMR.The synthesis conditions were also studied.The optimal process conditions of N-alkylation were as followed:reaction temperature 60℃,reaction time 0.5h,the ratio of benzocaine to 1-bromobutane was 1:4.6.

关 键 词：对硝基甲苯 苯佐卡因:苯佐卡因衍生物 

分 类 号：O625.41[理学—有机化学]