内源性活性物质2,3-吲哚醌抗前列腺增生作用  

Antagonistic Effects of Endogenous Active Substance Isatin on Benign Prostatic Hyperplasia

作　　者：郭春丽[1] 徐辉辉 师淑君[1] 龙腾腾[1] 李晓玲 岳旺[1] GUO Chunli;XU Huihui;SHI Shujun;LONG Tengteng;LI Xiaoling;YUE Wang(Qingdao Huanghai University,Qingdao 266427,China;Qingdao Municipal Hospital,Qingdao 266011,China)

机构地区：[1]青岛黄海学院,青岛266427 [2]青岛市立医院,青岛266001

出　　处：《医药导报》2018年第5期509-511,共3页Herald of Medicine

基　　金：国家科技部"重大新药创制"科技重大专项(2009ZX09102-050)

摘　　要：目的观察2,3-吲哚醌对前列腺增生的影响。方法健康雄性小鼠60只,随机分为6组(n=10):正常对照组,灌胃0.9%氯化钠溶液0.2 m L·d^(-1);模型对照组,皮下注射丙酸睾酮5 mg·kg^(-1),造模;前列康组,造模同时灌胃前列康5 mg·kg^(-1);2,3-吲哚醌小、中、大剂量组,造模同时分别灌胃2,3-吲哚醌25,50,100 mg·kg^(-1)。每天给药1次,连续15 d。末次用药后测定前列腺质量、前列腺指数,观察苏木精-伊红(HE)染色结果。结果 2,3-吲哚醌小、中、大剂量组小鼠前列腺指数分别为(61.04±0.96),(52.53±1.71),(43.78±2.08),均低于模型对照组(76.23±2.47)(P<0.05),上皮增生受到抑制。结论 2,3-吲哚醌可抑制丙酸睾酮诱发的小鼠前列腺增生。Objective To observe the effect of isatin on prostatic hyperplasia in model mice.Methods Sixty male mice were divided into six groups(n=10):normal control group(0.9%sodium chloride solution 0.2 mL·d-1,ig),model control group(testosterone propionate 5 mg·kg-1 hypodermic injection for modeling),Qianliekang group(Qianliekang 5 mg·kg-1,ig when modeling),isatin low-dose group(isatin 25 mg·kg-1,ig when modeling),isatin medial-dose group(isatin 50 mg·kg-1,ig when modeling),isatin high-dose group(isatin 100 mg·kg-1,ig when modeling).It was given once a day for 15 consecutive days.The prostate weight and prostate index were measured,and HE staining was observed.Results The prostate indexs of mice in low-,medial-and high-dose of isatin group were(61.04±0.96),(52.53±1.71)and(43.78±2.08),respectively,which were lower than in the model group(76.23±2.47)(P<0.05).Moreover,epithelial hyperplasia was inhibited.Conclusion Isatin could inhibit the prostatic hyperplasia of mice which was induced by testosterone propionate.

关 键 词：2 3-吲哚醌 丙酸睾酮 前列腺增生 

分 类 号：R983[医药卫生—药品] R697.32[医药卫生—药学]