酒精相关性横纹肌溶解症文献分析  

Document Analysis of Rhabdomyolysis Induced by Alcohol

作　　者：李秀华 LI Xiuhua(Pharmacy Department,Baodi District Haibin Hospital of Tianjin,Tianjin 301800,China)

机构地区：[1]天津市宝坻区海滨医院药房,天津301800

出　　处：《继续医学教育》2018年第4期105-107,共3页Continuing Medical Education

摘　　要：目的探讨酒精相关性横纹肌溶解症的临床特点、发生机制及治疗措施。方法以"酒精""横纹肌溶解"为检索词,检索Pub Med、CNKI数据库,对患者的一般情况、用药情况、横纹肌溶解症的临床表现、用药关联性、治疗与转归等进行分析。结果共纳入18篇文献,共计17例患者。联合使用他汀类药物1例,其余均为单独饮酒患者。6例患者存在明确饮酒史,单次饮酒量最高为1 000 ml,最低为150ml。意识改变,肌痛,尿少为主要临床表现。经过对症治疗后,16例痊愈,1例死亡。结论明确病史,早期诊断,及时去除病因,给予正确的治疗是降低死亡率的关键。Objective To discuss the clinical features,mechanism and treatment of alcohol-related rhabdomyolysis.Methods PubMed and CNKI databases were searched with the key words“alcohol”and“rhabdomyolysis”.The baseline characteristics of the patients,the situation of drug use,the clinical manifestation of rhabdomyolysis,medication association,treatment and outcome were analyzed.Results There were 18 cases reports referred to 17 patients suffering rhabdomyolysis induced by Alcohol.1 case used statins simultaneously.the rest were drinking alone.6 patients with a clear history of alcohol consumption,drink up to 1 000 ml one time,minimum 150 ml.Consciousness change,muscle pain,oliguria as the main clinical manifestations.After symptomatic treatment,16 cases recovered and 1 case died.Conclusion Clear history,early diagnosis,removal of the cause in time,to give the right treatment is the key to reducing mortality.

关 键 词：酒精 横纹肌溶解 P450肌酸激酶 

分 类 号：R595[医药卫生—内科学]