低出生体质量儿早期抗生素应用对肠道菌群和儿童期肥胖的影响  

Effects of Early Antibiotics Use on Intestinal Microflora and Childhood Obesity in Low Birth Weight Infants

作　　者：陈璐[1] 朱惠娟[1] 陈适[1] 潘慧[1] CHEN Lu;ZHU Huijuan;CHEN Shi;PAN Hui(Department of Endocrinology,Chinese Academy of Medical Science/Peking Union Medical College/Peking Union Medical College Hospital,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院内分泌科,北京100730

出　　处：《医学综述》2018年第4期703-707,共5页Medical Recapitulate

基　　金：中国医学科学院医学与健康科技创新工程项目(2016-I2M-1-008)

摘　　要：人类的生长发育与肠道菌群密不可分,生命早期是肠道菌群形成的重要时期,与成年后的代谢、免疫、消化等机体功能密切相关。低出生体质量儿与正常新生儿在生命早期肠道菌群的种类和数量有较大差异,这可能由生产方式、喂养办法不同及早期抗生素应用等原因干扰肠道菌群的定植过程所致。另外,低出生体质量儿儿童期肥胖的发生比例增加。这是因为早期抗生素应用引起肠道菌群的结构变化,对消化、免疫、生长发育等产生影响,从而导致儿童期肥胖的发生。因此,研究早期抗生素应用不仅能在一定程度上有效防止抗生素滥用,对疾病的治疗和患儿的正常生长发育有重要意义,还能为补充益生菌的数量和种类提供新方向。Human growth and development are closely related to intestinal microflora,and early life is an important period for the formation of intestinal microflora.It is closely related to the functions of metabolism,immunity,digestion and so on.There are great differences in the number and type of intestinal microflora between low birth weight infants and normal newborns at the early stage of life.This may be caused by different ways of delivery,feeding methods,and early antibiotic application,which interfere with the colonization process of intestinal microflora.In addition,the incidence of obesity in children with low birth weight increases in childhood.This is because that the early antibiotic application causes the structural change of intestinal microflora,and has an impact on digestion,immunity,growth and development,which leads to the occurrence of childhood obesity.Therefore,studying the early application of antibiotics can not only effectively prevent the abuse of antibiotics to a certain extent,but also play an important role in the treatment of diseases,as well as the normal growth and development of children.It can also provide new directions for the number and variety of probiotics supplement.

关 键 词：肠道菌群 儿童期肥胖 低出生体质量 抗生素 

分 类 号：R378[医药卫生—病原生物学]