孕中晚期fFN、阴道B超测宫颈长度预测无症状双胎妊娠早产的效果分析  

Effect of fFN and cervical length of vaginal ultrasound during the middle and late pregnancy to predict preterm delivery in asymptomatic twin pregnancy

作　　者：黄鹂鹂 HUANG Lili(Department of Obstetrics,Jiangmen Maternal and Child Health Hospital,Jiangmen 529300,China)

机构地区：[1]广东省江门市妇幼保健院产科,广东江门529300

出　　处：《中国医药科学》2018年第6期66-69,共4页China Medicine And Pharmacy

摘　　要：目的探讨孕中晚期纤维连接蛋白(f FN)、阴道B超测宫颈长度(CL)预测无症状双胎妊娠早产的效果分析。方法选择2016年4月~2017年3月于我院进行常规产检的无症状双胎妊娠孕妇90例为研究对象,于其孕24~34周测定CL和f FN,追踪统计孕妇的妊娠结局,并分析孕中晚期f FN和CL预测无症状双胎妊娠早产的临床价值。结果早产组孕中晚期f FN高于非早产组,CL低于非早产组,差异有统计学意义(P<0.05);f FN阳性早产率高于f FN阴性,差异有统计学意义(P<0.05);宫颈长度≤25mm早产率高于宫颈长度>25mm,差异具有统计学意义(P<0.05);经Spearman相关性分析,孕中晚期CL与无症状双胎妊娠早产率呈负相关(r=0.648,P<0.05),f FN与无症状双胎妊娠早产率呈正相关(r=0.714,P<0.05);进一步ROC曲线分析,孕中晚期f FN和CL预测无症状双胎妊娠早产具有良好的评估价值,二者联合预测无症状双胎妊娠早产的敏感性、特异性、准确性均高于单独应用f FN、CL,差异均有统计学意义(P<0.05)。结论孕中晚期f FN和CL对无症状双胎妊娠早产具有较高的预测价值,能够满足临床应用,值得在临床推广应用。Objective To discuss the effect of fFN and cervical length of vaginal ultrasound during the middle and late pregnancy to predict preterm delivery in asymptomatic twin pregnancy.Methods Ninety asymptomatic twin pregnancy women who underwent routine prenatal examination in our hospital from April 2016 to March 2017 were selected as the research subjects.CL and fFN were measured at 24-34 weeks of gestation,the pregnancy outcomes were tracked and analyzed,and the clinical value of fFN and CL in predicting preterm delivery in asymptomatic twin pregnancy was analyzed.Results In preterm delivery group,the fFN in the middle and late pregnancy was higher than that in the non preterm group,and the CL was lower than that in the non preterm group,the difference was statistically significant(P<0.05).The rate of fFN positive preterm delivery was higher than that of fFN negative,the difference was statistically significant(P<0.05).The premature rate of cervical length≤25 mm was higher than that of cervical length>25 mm,the difference was statistically significant(P<0.05).According to Spearman correlation analysis,there was a negative correlation between CL in the middle and late pregnancy and the premature delivery rate of asymptomatic twin pregnancy(r=0.648,P<0.05).There was a positive correlation between fFN and preterm labor rate of asymptomatic twin pregnancy(r=0.714,P<0.05).Further ROC curve analysis showed that fFN and CL in the middle and late pregnancy had good value in predicting asymptomatic twin pregnancy.The sensitivity,specificity and accuracy of the two combined prediction of preterm birth of asymptomatic twin pregnancy were higher than that of fFN and CL alone(P<0.05).Conclusion fFN and CL have high predictive value for preterm delivery of asymptomatic twin pregnancy in the middle and late pregnancy,which can meet the clinical application and is worthy of clinical application.

关 键 词：双胎妊娠 无症状 早产 纤维连接蛋白 宫颈长度 

分 类 号：R445.1[医药卫生—影像医学与核医学]