离子对负载L-脯氨酸阴离子催化下的不对称Aldol反应  

Ion-pair immobilization of L-proline anion and its catalytic performance for asymmetric Aldol reaction

作　　者：刘蝶丽 郭国长 赵晓伟[1] 崔元臣[1,2] LIU Dieli;GUO Guozhang;ZHAO Xiaowei;CUI Yuanchen(College of Chemistry and Chemical Engineering,Henan University,Kaifeng 475000,Henan,China;Engineering Research Center for Nanomaterials,Henan University,Kaifeng 475000,Henan,China)

机构地区：[1]河南大学化学化工学院,河南开封475000 [2]河南大学纳米材料工程研究中心,河南开封475000

出　　处：《化学研究》2018年第2期146-151,共6页Chemical Research

基　　金：河南省自然科学基金(1523004948826)

摘　　要：在水相中,通过阴阳离子结合使L-脯氨酸阴离子负载在基于Merrifield树脂的季铵根阳离子上,制备出功能性高分子离子液体.将该体系作为一种高效、可回收的催化剂用于催化醛与酮的不对称Aldol反应.结果表明:该催化体系在微量水中有很好的催化活性和立体选择性,相应的Aldol反应产物获得了6∶94的dr值以及高达98%的ee值,且该催化体系有较好的重复使用性能.L-Proline was loaded on the basis of quaternary ammonium cation based on Merrifield resin by ion pair in aqueous solution.The obtained heterogeneous catalyst was used to successfully catalyze direct asymmetric aldol reaction between aldehyde and ketone.The results show that the catalytic system has good catalytic activity and stereoselectivity in trace water,affording good enantioselectivity(up to 98%)and diastereoselectivity(up to 6∶94),and the catalyst system has good reusability.

关 键 词：Merrifield树脂 季铵根阳离子 L-脯氨酸 离子液体 ALDOL反应 

分 类 号：O621[理学—有机化学] O635[理学—化学]