医院儿科发生耐甲氧西林金黄色葡萄球菌感染的危险因素分析  

Risk factors of methicillin-resistant staphylococcus aureus infection in pediatrics

作　　者：徐礼君 胡秀萍[1] 陈新贵[1] XU Lijun;HU Xiuping;CHEN Xingui(Department of Clinical Pharmaceutics,Chuzhou First People′s Hospital,Chuzhou,Anhui 239001,China)

机构地区：[1]滁州市第一人民医院临床药学室,安徽滁州239001

出　　处：《安徽医药》2018年第5期991-994,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨医院儿科发生耐甲氧西林金黄色葡萄球菌(MRSA)感染的危险因素,为预防和控制其感染提供合理的依据。方法收集某医院儿科2016年6月—2017年6月期间的住院病历,采取对照的方法,以发生MRSA感染39例作为观察组,同期发生甲氧西林敏感金黄色葡萄球菌(MSSA)感染53例作为对照组,应用SPSS21.0统计软件进行单因素分析和非条件logistic多因素回归分析,探讨医院儿科MRSA发生感染的危险因素。结果在统计的时间范围内,单因素分析统计结果表明,病毒感染、使用抗菌药物的天数、三代头孢的应用、糖皮质激素的使用及住院天数与儿科发生MRSA感染相关联(P<0.05)。对筛选出的5项高危因素再进行非条件logistic回归分析,结果表明,病毒感染、使用抗菌药物的天数(较少)、不使用三代头孢、使用糖皮质激素是儿科发生MRSA感染的独立高危因素(P<0.05)。结论医院儿科发生MRSA感染的独立危险因素包括病毒感染、使用抗菌药物的天数、三代头孢的应用、糖皮质激素的使用。Objective To investigate the risk factors of methicillin resistant staphylococcus aureus(MRSA)infection in pediatric department,and to provide a reasonable basis for prevention and control of infection.Methods Medical records from June 2016 to June 2017 were collected in in pediatric department of the Hospital.Thirty-nine cases of MRSA infection were taken as the observation group,and 53 cases of methicillin sensitive staphylococcus aureus(MSSA)infection as control group.SPSS21.0 statistical software for single factor and non-conditional logistic regression analysis was used to explore the risk factors of hospital pediatric MRSA infection.Results In the statistical time range,the statistical results of the single factor showed that the virus infection,days of use of antimicrobial agents,application of three generation cephalosporin,the use of glucocorticoids and hospitalization days were risk factors of MRSA infection in pediatrics(P<0.05).On 5 risk factors selected for analysis,non-conditional logistic statistical results showed that the virus infection,days of use of antimicrobial agents(relatively few),disuse of three generation cephalosporin,and use of glucocorticoids were independent high-risk factors of MRSA infection in pediatrics(P<0.05).Conclusions The independent risk factors of MRSA infection in hospital pediatrics include virus infection,days of use of antimicrobial agents,application of three generation cephalosporin,and use of glucocorticoids.

关 键 词：耐甲氧西林金黄色葡萄球菌 儿科院内感染 危险因素 

分 类 号：R446.5[医药卫生—诊断学]