哮喘患儿诱导痰中炎性细胞与IL-17含量相关性分析  

CORRELATION OF THE IL-17 LEVELS AND THE INFLAMMATORY CELLS IN INDUCED SPUTUM OF CHILDREN WITH ASTHMA

作　　者：张晓蒙[1] 任少敏[1] 朝鲁门其其格 苏秦[1] ZHANG Xiao-meng;REN Shao-min;CHAO Lu Mengqiqige(The Affiliated Hospital,Inner Mongolia Medical University,Hohhot 010050 China)

机构地区：[1]内蒙古医科大学附属医院儿科,内蒙古呼和浩特010050

出　　处：《内蒙古医科大学学报》2018年第1期62-65,共4页Journal of Inner Mongolia Medical University

基　　金：内蒙古自治区自然科学基金(2012MS1120)

摘　　要：目的:探讨不同时期儿童支气管哮喘病人诱导痰中炎性细胞与IL-17的相关性,揭示IL-17参与哮喘发病的可能机制。方法:引入诱导痰液检查和ELISA检测技术,收集急性发作期24例、临床缓解期3mo 23例和临床缓解期6mo 22例,正常对照组22名,检测其诱导痰液中IL-17的含量和炎性细胞百分比,并分析两种炎性细胞在哮喘不同时期与IL-17的相关性。结果:IL-17含量与中性粒细胞百分比在急性发作期组成正相关,而与嗜酸性粒细胞无相关关系。结论:表明了IL-17和中性粒细胞参与了儿童哮喘气道局部炎症的发病,可能参与哮喘的部分发病机制。Objective:Discussion correlation of the IL-17 levels and the inflammatory cells in induced sputum of children with asthma in different periods,and reveal the possible mechanisms of IL-17 involved in the pathogenesis of asthma.Methods:Introduce the induced sputum examination and ELISA techniques,and collecting 24 asthma cases at acute exacerbation periods,23 cases at clinical remission of 3months and 22 cases of clinical remission 6months,22 cases of the control group.Detect the IL-17 levels and the percentage of inflammatory cells of induced sputum,and analyze the correlation of different inflammatory cells with IL-17 in different periods of asthma.Results:IL-17 levels reveal positive correlation with the percentage of neutrophils at acute exacerbation periods,but no correlation with eosinophils.Conclusion:The results confirmed that IL-17 and neutrophils may involve in part of the pathogenesis of asthma.

关 键 词：支气管哮喘 儿童 诱导痰 白细胞介素-17 炎性细胞 

分 类 号：R562.25[医药卫生—呼吸系统]