骨骼肌减少与动脉粥样硬化共同发病机制的研究进展  

ADVANCES INSTUDIES ON THE COMMON PATHOGENESIS OF SARCOPENIA AND ATHEROSCLEROSIS

作　　者：刘颖[1] 高金娥 LIU Ying;GAO Jin-e(Baotou Medical College,Baotou 014000 China)

机构地区：[1]包头医学院,内蒙古包头014000 [2]内蒙古自治区人民医院老年医学中心,010017

出　　处：《内蒙古医科大学学报》2018年第1期89-93,共5页Journal of Inner Mongolia Medical University

基　　金：国家自然科学基金(81460223);内蒙古自治区自然科学基金(2016MS0869);内蒙古自治区卫生和计划生育委员会医疗卫生科研计划项目(201301006);内蒙古自治区科技计划项目基金(2017)

摘　　要：随着年龄的增长,骨骼肌减少与动脉粥样硬化的发病率显著升高。近年来大量临床研究表明二者具有密切的相关性。然而骨骼肌减少导致动脉粥样硬化的机制并不确切。可能的机制包括:胰岛素抵抗、性激素水平下降、细胞因子炎症因子、自由基损伤、营养不良、低出生体重、细胞凋亡、线粒体损伤、卫星细胞作用。进行阻抗运动、增加蛋白质摄入、补充维生素D等措施对防治老年动脉粥样硬化有效。因此,有必要对二者相关的机制进行更深入、广泛的研究。As the growth of the age,significantly increased the incidence of sarcopenia and atherosclerosis.In recent years a large number of clinical studies have shown that both have close correlation.However,the mechanism on how sarcopenia leads to atherosclerosis is not very clear yet.Including the possible mechanism:Insulin resistance,sex hormone levels drop,inflammatory cytokine factor,free radical damage,malnutrition,low birth weight,cell apoptosis,mitochondrial damage,satellite cells.Impedance movement,increase the protein intake,vitamin D supplement measures may be the possible prevention and treatment of senile atherosclerosis.Therefore,indepth and extensive reseaches are necessary in elucidating the underlying mechanisms.

关 键 词：骨骼肌减少 动脉粥样硬化 共同发病机制 

分 类 号：R543.5[医药卫生—心血管疾病]