拉莫三嗪联合小剂量丙戊酸治疗新诊断癫痫的临床疗效观察  

Clinical Efficacy of Lamotrigine in Combination With Low Dose Valproic Acid in the Treatment of Newly Diagnosed Epilepsy

作　　者：殷卓琳[1] YIN Zhuolin(Department of Neurology,Jilin People's Hospital,Changchun Jilin 130021,China)

机构地区：[1]吉林省人民医院神经内科,吉林长春130021

出　　处：《中国继续医学教育》2018年第13期97-99,共3页China Continuing Medical Education

摘　　要：目的分析拉莫三嗪联合小剂量丙戊酸治疗新诊断癫痫的临床疗效。方法选取2015年1月—2017年1月我院收治的82例新诊断癫痫患者作为研究对象,将其随机分为两组,每组各41例。研究组联合应用拉莫三嗪和小剂量丙戊酸,对照组仅选丙戊酸,比较两组患者的疗效。结果研究组患者的治疗有效率高于对照组,差异具有统计学意义(P<0.05),不良反应发生率低于对照组,但数据对比,差异无统计学意义(P>0.05),临床指标均优于对照组,但数据对比,差异无统计学意义(P>0.05)。结论拉莫三嗪联合小剂量丙戊酸治疗新诊断癫痫疗效显著。Objective To analyze the clinical efficacy of lamotrigine in combination with low dose valproic acid in the treatment of newly diagnosed epilepsy.Methods 82 cases of newly diagnosed epilepsy in our hospital from January 2015 to January 2017 were selected as the research subjects.They were randomly divided into two groups,41 cases in each group.The research group combined with small dose of lamotrigine and valproate.In the control group,valproic acid was selected only.The effects of the two groups were compared.Results The effective rate of the study group was higher than that of the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions was lower than that of the control group,but the difference was not statistically significant(P>0.05).The clinical indicators were better than those in the control group,but there was no significant difference in data comparison(P>0.05).Conclusion Lamotrigine combined with small doses of valproic acid treatment of new diagnosis of epilepsy significant effect.

关 键 词：癫痫 拉莫三嗪 丙戊酸 

分 类 号：R473[医药卫生—护理学]