双相障碍患者心肌酶活性变化及心电图表现分析  

Changes in myocardial enzyme activities and ECG results in patients with bipolar disorder

作　　者：苏希跃 卢大力 谢珊珊 洪梅芬 SU Xiyue;LU Dali;XIE Shanshan;HONG Meifen(Xiamen Xianyue Hospital,Xiamen Fujian 361012,China)

机构地区：[1]厦门市仙岳医院,福建厦门361012

出　　处：《中国民康医学》2018年第5期14-16,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨双相障碍患者躁狂相与抑郁相心肌酶谱和心电图变化。方法:收集772例双相障碍患者的一般资料,含躁狂相组370例,抑郁相组402例,收集同期在体检中心体检健康者184例为对照组。血清测定肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)等生化项目及常规心电图并进行对比分析。结果:治疗前躁狂相组的CK、CK-MB、LDH活性显著高于抑郁相组和健康对照组,比正常参考值高几倍到上百倍,且其差异具有统计学意义(P<0.05)。抑郁相组的心肌酶活性与健康对照组差异明显(P<0.05)。躁狂相组经二周治疗后心肌酶水平显著下降(P<0.05)。常规心电图检查躁狂相组心率显著高于抑郁相组和健康对照组(P<0.05)。结论:心肌酶的增高与躁狂相患者病情严重程度呈正相关,可作为双相障碍的一个生物学指标。Objective:To investigate changes of myocardial enzyme spectrum and ECG in patients in manic and depressive phases of bipolar disorder.Methods:The general data of 700 bipolar disorder patients(370 were in manic phase,and 402 were in depressive phase)and 184 healthy cases(as control group)for health examination at the same time were collected.The levels of serum creatine kinase(CK),creatine kinase isoenzyme(CK-MB),lactate dehydrogenase(LDH))and ECG parameters were determined and compared.Results:Prior to the treatment,the activities of CK,CK-MB and LDH in the manic phase group(several times to hundreds of times higher than the normal reference)were significantly higher than those in the depressive group and the control group,and the differences were statistically significant(P<0.05).Moreover,there were significant differences in the myocardial enzyme activity between the depressive group and the control group(P<0.05).After two weeks of treatment,the manic group experienced a significant decrease in the levels of cardiac enzymes(P<0.05).ECG results demonstrated a significantly higher level of heart rate in the manic group than in the depressive group and the control group(P<0.05).Conclusions:There is a positive correlation between the manic patients'myocardial enzyme level increase and the severity of his/her condition.Therefore,this parameter can be used as a biological indicator for diagnosing bipolar disorder.

关 键 词：双相情感障碍 躁狂相 抑郁相 心肌酶谱 心电图 

分 类 号：R540.41[医药卫生—心血管疾病] R749.4[医药卫生—内科学]