血清NGAL和Cystatin C对高尿酸血症肾损害早期诊断的意义  

The Significance of Serum NGAL and Cystatin C in the Early Diagnosis of Hyperuricemia Renal Damage

作　　者：顾谊铮[1] 岑俊[1] 唐云海[1] 杨德玉[1] 魏勇[1] GU Yizheng;CEN Jun;TANG Yunhai(Jiangong Hospital of Shanghai,Shanghai 200083,China)

机构地区：[1]上海建工医院,上海200083

出　　处：《中外医学研究》2018年第9期1-3,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：虹口区卫生和计划生育委员会科研课题项目(项目编号:虹卫1202-08)

摘　　要：目的:探讨高尿酸血症患者血清NGAL和Cystatin C的改变及其对肾功能损害早期诊断的临床意义。方法:体检者中选择高尿酸血症147例,根据尿白蛋白/肌酐比值(UACR)分为3组,正常蛋白尿(NA)组72例、微量蛋白尿(MA)组45例、临床肾病(CN)组30例;选择尿酸正常的体检者30例为对照组。应用ELISA法检测患者血清NGAL和Cystatin C水平,分析二者与肾小球滤过率(GFR)之间的相关性。结果:(1)NA组的Bun、Cr、GFR、NGAL和Cystatin与对照组相比,差异均无统计学意义(P>0.05)。MA组的GFR、NGAL、Cystatin C与对照组、NA组相比,差异有统计学意义(P<0.01)。CN组与各组相比,Bun、Cr升高,GFR明显降低,NGAL和Cystatin与对照组、NA、MA组相比,差异均有统计学意义(P<0.01)。(2)对照组与各高尿酸组血清NGAL和Cystatin C水平与GFR的相关性分析表明,将血清NGAL值进行函数转换,In NGAL和Cystatin与GFR均呈负相关。结论:高尿酸血症患者血清NGAL和Cystatin C与GFR有较好的相关性,能准确反映肾功能损害的程度,是高尿酸血症肾损害早期诊断指标,有望用于临床。Objective:To investigate the changes of serum NGAL and Cystatin C in patients with hyperuricemia and their clinical significance in early diagnosis of renal dysfunction.Method:Selected 147 cases of hyperuricemia in patients,according to urinary albumin/creatinine ratio(UACR),were divided into three groups:normal albuminuria group(NA)of 72 cases,microalbuminuria(MA)group of 45 cases,proteinuria(CN)group of 30 cases.Selection of physical examination population normal uric acid in 30 cases as the control group.NGAL and Cystatin C in patients with serum levels of two were analyzed using ELISA method,and glomerular filtration rate(GFR)correlation.Result:(1)NA group of Bun,Cr,GFR,NGAL and Cystatin compared with the control group,there were no significant difference(P>0.05).MA group of GFR,NGAL,Cystatin C compared with control group,NA group,the difference was statistically significant(P<0.01).CN group compared with the other groups,Bun,Cr increased significantly,GFR decreased,NGAL and Cystatin,compared with the control group,NA,MA group,the difference was statistically significant(P<0.01).(2)The control group and high uric acid serum levels of NGAL and Cystatin C,the correlation between the level and GFR.The function of serum NGAL was converted,and NGAL and Cystatin C were negatively correlated with GFR.Conclusion:The serum levels of NGAL and Cystatin C are correlated with GFR in patients with hyperuricemia.It can accurately reflect the extent of renal damage and is an early diagnostic indicator of hyperuricemia and renal damage.It is expected to be used in clinical monitoring.

关 键 词：中性粒细胞明胶酶载脂蛋白 半胱氨酸蛋白酶抑制剂C 高尿酸血症 

分 类 号：R589.7[医药卫生—内分泌] R692[医药卫生—内科学]