丙泊酚对老年犬心肌缺血再灌注损伤的影响  

The Effects of Propofol on Myocardial Ischemia Reperfusion Injury in Aged Canines

作　　者：董婧[1] 温吉昱 陈玉婷 徐云泽 星启明 李林[1] DONG Jing;WEN Ji-yu;CHEN Yu-ting;XU Yun-ze;XING Qi-ming;LI Lin(College of Animal Science and Veterinary Medicine,Shenyang Agricultural University,Shenyang 110161,China)

机构地区：[1]沈阳农业大学畜牧兽医学院,沈阳110161

出　　处：《沈阳农业大学学报》2018年第2期209-213,共5页Journal of Shenyang Agricultural University

基　　金：国家自然科学基金项目(31772805;31302149)

摘　　要：通过检测各种指标评估缺血再灌注过程对老年犬造成的损伤,并探讨丙泊酚对老年犬心肌缺血再灌注损伤的影响,本研究选取20只健康犬(7~9岁),随机分为2组(n=10):对照组(C组)和异丙酚组(P组)。C组注入60mL·h^(-1)生理盐水于股静脉补充体液流失。P组用丙泊酚按90μg·kg^(-1)·min^(-1)进行维持麻醉。开胸阻断左冠脉前降支(LAD)90min后再灌注200min,于注药前、注药60min、阻断90min以及再灌注60,120和180min时,分别测定和计算心率(HR),体循环指标包括平均动脉压(MAP)、中心静脉压(CVP)、肺循环指标包括肺动脉压(PAP)、肺动脉嵌压(PCWP)。P组在LAD阻断前,异丙酚应用1h后老年犬的HR下降;在缺血再灌注期间老年犬的HR变化相对较小。与LAD阻断前相比,C组在LAD阻断后和再灌注期间老年犬的HR比显著上升(p<0.05),并高于同时间点P组HR(p<0.05)。C组老年犬的MAP在阻断后比阻断前降低(p<0.05),其他各组老年犬的MAP、CVP差异不显著。在阻断后和再灌注期间各组的老年犬的PAP比阻断前增加显著(p<0.05),各组间相差不显著。C组老年犬的PCWP阻断后和再灌注期间比阻断前均极显著增加(p<0.01),高于同时间点P组老年犬的指标(p<0.05);P组老年犬的PCWP阻断后比阻断前增加(p<0.05),而再灌注期间变化不显著。丙泊酚对老年犬心肌缺血再灌注损伤时的心肌具有一定保护作用。The aim of this study was to evaluate the effects of propofol on the myocardial ischemia reperfusion injury(MIRI)in aged dogs.Eighteen healthy aged mongrel dogs(7-9 years old)were divided into C group(normal saline,60mL·h-1)and P group(propofol,90μg·kg-1·min-1).These dogs were administered the left anterior descending coronary artery occlusion for 90 min then followed reperfusion for 200 min.The parameters of heart rate(HR),mean arterial pressure(MAP),central venous pressure(CVP),pulmonary artery pressure(PAP),Pulmonary capillary wedge pressure(PCWP)were measured before administration(T0),at 60 min after administration,at occlusion 90 min and reperfusion 60,120 and 180 min.The results showed that the change of HR caused by MIRI in P group was significantly smaller than that in C group.The values of MAP at T2 decreased compared with the T0 in C group(p<0.05).The values of PAP in two groups were significantly increased after occlusion and during reperfusion(p<0.05).but The values of PCWP in C group after occlusion and during reperfusion were significantly increased than the value before occlusion(p<0.01).In conclusion,propofol could protect the function of systemic circulation,pulmonary circulation during MIRI in aged dogs.Our current research could lay a foundation for further clinical trials in the use of propofol in veterinary surgery.

关 键 词：丙泊酚 心肌缺血 再灌注损伤 老年犬 麻醉药 

分 类 号：S625.5[农业科学—园艺学]