家畜基因组中拷贝数变异与性状相关性的研究进展  

Research Progress on the Correlation between Copy Number Variation and Trait in Domestic Animal Genome

作　　者：王月星[1,2] 王艳欣 王位[1,2] 刘娜娜 段仕[1,2] 付绍印 刘永斌 张文广 WANG Yue-xing;WANG Yan-xin;WANG Wei;LIU Na-na;DUAN Shi;FU Shao-yin;LIU Yong-bin;ZHANG Wen-guang(College of Animal Science,Inner Mongolia Agricultural University,Hohhot 010018,China;Key Laboratory of Animal Genetics,Breeding and Reproduction of Inner Mongolia,Hohhot 010018,China;Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences,Hohhot 010031,China;Institute of ATCG Bio-information of Inner Mongolia,Hohhot 010020,China)

机构地区：[1]内蒙古农业大学动物科学学院,内蒙古呼和浩特010018 [2]动物遗传育种与繁殖内蒙古自治区重点实验室,内蒙古呼和浩特010018 [3]内蒙古自治区农牧业科学院,内蒙古呼和浩特010031 [4]内蒙古ATCG生物信息研究所,内蒙古呼和浩特010020

出　　处：《畜牧与饲料科学》2018年第4期38-40,共3页Animal Husbandry and Feed Science

基　　金：国家自然科学基金项目(31560622;31672385;31260538;30960246)

摘　　要：家畜基因组中的CNV长度跨度较大,可以包含1个基因或基因的一部分,也可以跨越多个基因,在基因组中覆盖的核苷酸总数远远超过SNP总数。已有研究表明,CNV可以影响基因表达。介绍了在不同家畜基因组中的CNV相关研究,并对这些CNVs与性状的相关性进行分析,总结了CNV对性状的影响,展望了家畜基因组中CNV对表型影响的研究动态及进展,以期为家畜基因组中CNV的进一步研究及对表型性状的影响提供参考。The copy number variation(CNV)in domestic animal genome has relatively larger span length which always contains a single gene or a part of a certain gene and even spans multiple genes.The total number of nucleotides covered by CNV is much larger than the total number of SNPs.Some studies have showed that the CNV can affect gene expression.In this paper,we introduce the researches on CNV in different domestic animal genome,analyze the correlation between these CNVs and trait,summarize the impact of CNV on trait,and review the progress and prospect of the studies on effect of CNV on trait in domestic animal genome,in hoping to offer references for the further research on CNV in domestic animal genome and its impact on the phenotypic traits.

关 键 词：基因组 CNV 家畜 

分 类 号：S813[农业科学—畜牧学]