壳聚糖复合材料在骨修复领域的研究进展  

Research progress of chitosan composite materials in bone repair

作　　者：陆遥 尹庆水[1] 夏虹[1] LU Yao;YIN Qingshui;XIA Hong(Hospital of Orthopaedics,Institute of Traumatic Orthopaedics of PLA,Guangzhou General Hospital of Guangzhou Military Command,Guangzhou,Guangdong 510010,China)

机构地区：[1]广州军区广州总医院骨科医院全军创伤骨科研究所,510010

出　　处：《中国骨科临床与基础研究杂志》2018年第1期46-52,共7页Chinese Orthopaedic Journal of Clinical and Basic Research

基　　金：国家自然科学基金项目(21620102004)

摘　　要：壳聚糖是一种具有良好生物安全性和特殊生物活性的天然多糖,与其他材料复合后可用于骨缺损修复,临床应用潜力巨大。本文介绍壳聚糖复合天然聚合物材料在骨修复领域的应用,综述壳聚糖生物活性玻璃骨修复材料的研究进展,总结人工合成聚合物、微纳米材料等与壳聚糖复合后对骨修复的促进作用,同时对其未来的发展方向和应用前景进行展望。Being a natural polysaccharide with good biocompatibility and unique bioactivity,chitosan has been shown promising potential for clinical application when used in repair of bone defects as a composite with other materials.In this paper,the application of chitosan-natural polymers composite in bone repair was introduced,research progress of bone repair materials of bioactive ceramics with chitosan was reviewed,the promotion roles of chitosan combined with artificial synthesized polymers,micro nanomaterials etc.on bone repairing were summarized,furthermore,future direction of development and application prospect of the above chitosan composite materials were looked forward.

关 键 词：壳多糖 藻酸盐 陶瓷制品 羟基磷灰石类 乳酸盐类 聚合物 纳米复合物 骨代用品 生物相容性材料 骨修复 

分 类 号：R68[医药卫生—骨科学] R318.17[医药卫生—外科学]