白介素-6在银屑病中的研究进展  

Interleukin-6 in Psoriasis

作　　者：王文明[1] 晋红中[1] WANG Wenming;JIN Hongzhong(Department of Dermatology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China)

机构地区：[1]中国医学科学院,北京协和医学院,北京协和医院皮肤科,北京100730

出　　处：《中国医学科学院学报》2018年第2期284-288,共5页Acta Academiae Medicinae Sinicae

基　　金：中国医学科学院医学与健康科技创新工程协同创新团队项目(2017-I2M-3-020)

摘　　要：银屑病为一种常见的多因素参与的慢性炎症性疾病,其发病机制尚未完全清楚。在银屑病皮损中存在多种细胞因子的表达增高,并且血清中细胞因子的升高与疾病的严重度相关。白介素-6为一种多功能的促炎因子,被证实参与到包括银屑病在内的多种自身免疫性及慢性炎症性疾病中。本文主要综述白介素-6在银屑病中的研究进展。Psoriasis is a common,multifactorial,chronic inflammatory skin disease with an incompletely understood pathogenesis.A substantial number of inflammatory cytokines have been found to be elevated in psoriatic lesions,and the serum levels of a subset of these cytokines also correlate with the severity of psoriasis.Interleukin-6 is a multifunctional pro-inflammatory cytokine.Interleukin-6 is proved to be associated with many chronic inflammatory diseases and autoimmunity diseases such as psoriasis.This article reviews the relationship between interleukin-6 and psoriasis.

关 键 词：白介素-6 银屑病 TH17细胞 TREG细胞 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]