注意力调控感觉信息处理的脑功能区研究  

An fMRI study of human brain areas involved in attentional modulation of sensory processing

作　　者：龚涛 陈家英 张丽[2,3] 胡理 梁猛 GONG Tao;CHEN Jia-ying;ZHANG Li(School of Medical Imaging,Tianjin Medical University,Tianjin 300203,China)

机构地区：[1]天津医科大学医学影像学院,天津300203 [2]北京大学心理与认知科学学院,北京100871 [3]北京大学脑科学与认知科学中心,北京100871 [4]中国科学院心理健康重点实验室(中国科学院心理研究所),北京100101 [5]中国科学院大学心理学系,北京100049

出　　处：《放射学实践》2018年第4期349-353,共5页Radiologic Practice

基　　金：天津市应用基础与前沿技术研究计划一般项目(15JCYBJC55100);国家自然科学基金面上项目(81571659)

摘　　要：目的:探讨注意力在感觉信息处理的调控过程中的相关脑功能区。方法:23个健康被试行功能磁共振成像(fMRI)检查并接受触觉、视觉和听觉三种不同模态的感觉刺激。根据实验指令,被试需在实验的不同时段将注意力分别集中于触觉刺激或视觉刺激。对不同感觉刺激在不同注意力水平下的激活脑区进行了比较分析,并提取出不同感觉刺激条件下神经活动受到注意力调控的公共脑区。结果:采用团块水平的family-wise error(FWE)多重比较校正方法(团块定义阈值P<0.001,校正后阈值P<0.05),发现被试接受触觉和视觉刺激时神经活动受到注意力调控的公共脑区包括双侧额中回、右侧额下回,右侧顶下小叶、右侧前中扣带回、双侧脑岛、左侧尾状核、左侧辅助运动区以及左侧小脑。结论:额叶、顶叶部分区域、前扣带回以及双侧脑岛在注意力对感觉信息处理相关神经活动的调控中起到重要作用。Objective:To investigate the brain areas that were involved in the attentional modulation during sensory processing.Methods:Twenty-three healthy participants were recruited and examined using functional magnetic resonance imaging(fMRI)while receiving tactile,visual and auditory stimulation.During the experiment,subjects'attention was directed to either tactile or visual stimuli.We identified the brain areas whose activity elicited by tactile or visual stimuli was modulated by attention.We further identified the common areas whose activity was modulated by attention during both tactile and visual stimulation.These common areas were considered to be involved in attention modulation during sensory processing general to all sensory modalities,rather than specific to a particular modality.Results:Using cluster-level family-wise error(FWE)multiple comparison correction method(cluster defining threshold P<0.001,corrected P<0.05),we found that during both tactile and visual stimulation,the brain areas whose activity increased when subjects'attention was directed to the sensory stimuli of the corresponding modality including bilateral middle frontal gyri,the right inferior frontal gyrus,the right inferior parietal lobule,the right anterior and the mid-cingulate cortex,bilateral insula,the left caudate nucleus,the left supplementary motor area and the left cerebellum.Conclusion:These brain areas located in the frontal,parietal and cingulate cortices and the insula may play an important role in attentional modulation during sensory processing.

关 键 词：功能磁共振成像 感觉信息处理 注意力调控 

分 类 号：R445.2[医药卫生—影像医学与核医学]