对一例罕见头状地霉肺炎的治疗和体会  

Treatment and experience of a patient with rare Geotrichum capitatum pneumonia

作　　者：李平 卜书红[2] 陈峰[3] 刘瑛[3] 刘芳[4] 何慧敏[4] 祁红[1] LI Ping;BU ShuHong;CHEN Feng;LIU Ying;LIU Fang;HE HuiMin;QI Hong(Department of Pharmacology and Chemicobiology,School of Medicine,Shanghai Jiaotong University,Shanghai 200025,China;Department of Pharmacy,Xinhua Hospital Affiliated to School of Medicine,Shanghai Jiaotong University,Shanghai 200092,China;Department of Clinical Laboratory,Xinhua Hospital Affiliated to School of Medicine,Shanghai Jiaotong University,Shanghai 200092,China;Department of Geriatric,Xinhua Hospital Affiliated to School of Medicine,Shanghai Jiaotong University,Shanghai 200092,China)

机构地区：[1]上海交通大学医学院药理与化学生物学系,上海200025 [2]上海交通大学医学院附属新华医院药学部,上海200092 [3]上海交通大学医学院附属新华医院检验科,上海200092 [4]上海交通大学医学院附属新华医院老年医学科,上海200092

出　　处：《药学服务与研究》2018年第2期96-100,116,共6页Pharmaceutical Care and Research

摘　　要：目的:介绍一例罕见的头状地霉肺炎的治疗方法以及药学服务经验。方法和结果:临床药师参与一例高龄头状地霉肺炎病人的治疗过程。通过查阅文献制定了氟康唑联合氟胞嘧啶的治疗方案,该病人对治疗反应较好,但治疗1个月仍不足以根除病菌,复发后再次合用氟康唑和氟胞嘧啶治疗2个月可彻底治愈。作者保留了菌种,6个月后通过体外联合药敏试验进行了验证。结论:氟胞嘧啶与氟康唑联合治疗头状地霉肺炎方案具有效性、安全性和经济性。体外联合药敏试验亦验证了该方案的有效性。Objective:To introduce the treatment of a patient with rare Geotrichum capitatum pneumonia and pharmaceuti-cal care experience.Methods and Results:Clinical pharmacists were directly involved in the treatment of an old patient with Geotrichum capitatum pneumonia.The treatment regimen by combined medication of fluconazole and flucytosine was developed through consultation of related literature,and the patient responded quite well to the treatment.However,1 month of treat-ment was not sufficient to eradicate Geotrichum capitatum.After relapse,combined medication of fluconazole and flucytosine for another 2 months could completely cure the disease.The bacteria were retained and drug efficacy was verified through com-bined drug sensitivity test in vitro,6 months later.Conclusion:Fluconazole combine with flucytosine is an effective,safe and economic treatment method for Geotrichum capitatum pneumonia.

关 键 词：头状地霉 肺炎 氟康唑 氟胞嘧啶 微生物敏感性试验 临床药师 

分 类 号：R978.5[医药卫生—药品] R563.1[医药卫生—药学]