小鼠椎间盘退变模型实验进展  

The experimental progress of mouse disc intervertebral degeneration models

作　　者：刘佳鑫 崔颖[2] 徐海栋[2] LIU Jia-Xin;CUI Ying;XU Hai-Dong(193864 Military Hostipal,Changji 831112,China;Nanjing General Hospital of Nanjing Military Command,Nanjing 210002,China)

机构地区：[1]新疆维吾尔自治区昌吉市93864部队医院,新疆昌吉831112 [2]南京军区南京总医院,江苏南京210002

出　　处：《转化医学电子杂志》2018年第3期52-54,共3页E-Journal of Translational Medicine

基　　金：国家自然科学基金青年基金项目(81501925);中国博士后科学基金(2016M593038)

摘　　要：建立动物椎间盘退变模型是研究椎间盘退行性变的重要方式。目前常用的小鼠椎间盘退变模型分为生物力学模型、物理损伤模型、基因敲除模型和化学损伤模型。本文就以上几种模型的内容及其特点作一综述。Establishment of animal intervertebral disc degeneration model is an important way for the research of disc degeneration.At present,the commonly used mouse ntervertebral disc degeneration models are divided into the following types;biomechanical model,physical damage model,gene knockout model and chemical damage model.In this paper,the contents of the above models and its characteristics are reviewed.

关 键 词：椎间盘退变 动物模型 损伤 

分 类 号：R681.5[医药卫生—骨科学]