阿司匹林抵抗的研究进展  

Research Progress of Aspirin Resistanc

作　　者：孙涛[1] 于建设[2] SUN Tao;YU Jianshe(Inner Mongolia Medical University,Hohhot 010000,China;Department of Anesthesiology,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010000,China)

机构地区：[1]内蒙古医科大学,呼和浩特010000 [2]内蒙古医科大学附属医院麻醉科,呼和浩特010000

出　　处：《医学综述》2018年第5期853-857,共5页Medical Recapitulate

基　　金：内蒙古自治区自然科学基金(2015MS0832)

摘　　要：血小板在动脉粥样硬化斑块的形成和斑块破裂后的急性血栓事件中起关键作用,阿司匹林可有效抑制血小板聚集,血栓形成显著减少。阿司匹林被广泛用于心脑血管疾病一级预防和二级预防,但仍有大量患者发生血栓事件,如阿司匹林治疗失败或阿司匹林抵抗。阿司匹林抵抗经常伴随着不稳定斑块、心血管事件和脑血管意外的高发病率。研究表明,阿司匹林可减少血栓素A_2的生成,但不完全抑制血小板的活性。Platelets play a key role in the formation of atherosclerotic plaques and acute thrombotic events after plaque rupture.Aspirin can effectively inhibit platelet aggregation and thrombosis is significantly reduced.Aspirin is the most widely prescribed drug for the primary and secondary prevention of cardiovascular and cerebrovascular diseases.However,a large number of patients taking aspirin therapy continue to experience thromboembolic events,a phenomenon referred to as aspirin resistance or treatment failure.Aspirin resistance is often associated with a high incidence of unstable plaque,cardiovascular events and cerebrovascular accident.The study has shown that aspirin reduces the formation of thromboxane A 2,but does not completely inhibit the activity of platelets.

关 键 词：阿司匹林抵抗 单核酸多态性 炎症 代谢综合征 微RNA 

分 类 号：R917[医药卫生—药物分析学]