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作 者:李虹[1] 孔志斌[1] LI Hong;KONG Zhibin(Department of Respiration,Shanghai Sixth People′s Hospital East Affiliated to Shanghai University of Medicine&Health Sciences,Shanghai 201306,China)
机构地区:[1]上海健康医学院附属第六人民医院东院呼吸科,上海201306
出 处:《医学综述》2018年第5期858-862,共5页Medical Recapitulate
基 金:上海健康医学院2017年度校种子基金(HMSF-17-22-022)
摘 要:辅助性T细胞17(Th17细胞)在防止感染和介导自身免疫性疾病方面具有重要作用,但其机制尚不完全清楚。而白细胞介素(IL)26是Th17细胞分泌的重要细胞因子,它在自身免疫性疾病(类风湿关节炎、炎症性肠病)的慢性炎症过程中发挥重要作用;其所具有的独特阳离子两亲性蛋白结构可通过膜孔形成杀死细胞外细菌,与细菌DNA或死亡细菌和宿主细胞释放的细胞外DNA形成复合物,激活Toll样受体9,产生α干扰素、肿瘤坏死因子α等,为Th17细胞提供有力的免疫防御功能。未来,有望通过调节Th17细胞/IL-26功能,增强宿主抗微生物活性或控制自身免疫性疾病的炎症反应,为抗感染免疫防御提供新治疗策略。Helper T cell 17(Th17 cell)plays a major role in preventing infection and mediating autoimmune diseases,but its mechanisms is not yet completely clear.Interleukin(IL)26 is an important cytokine secreted by Th17 cell in autoimmune diseases(rheumatoid arthritis,inflammatory bowel disease),playing an important role in the chronic inflammatory process;it has unique cationic amphiphilic protein structure which can kill extracellular bacteria through membrane pores,and form complexes with bacterial DNA or extracellular DNA death released by bacteria and host cells,activate Toll like receptor 9,produce tumor necrosis factorα,interferonα,etc.,providing a powerful immune defense function for Th17 cell.In the future,it is expected to provide new therapeutic strategies for anti-infective immune defense by regulating the function of Th17 cell/IL-26,enhancing host antimicrobial activity or controlling the inflammatory response of autoimmune diseases.
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