PDGF和PDGFR在烟雾病中的研究进展  

Research and Development of the PDGF and PDGFR in Moyamoya Disease

作　　者：朱磊 李育平[1] 张恒柱[1] ZHU Lei;LI Yuping;ZHANG Hengzhu(Department of Neurosurgery,Northern Jiangsu People′s Hospital,Yangzhou 225001,China)

机构地区：[1]江苏省苏北人民医院神经外科,江苏扬州225001

出　　处：《医学综述》2018年第5期863-867,共5页Medical Recapitulate

基　　金：扬州市重点研发计划(YZ2015046)

摘　　要：烟雾病是一种病因不明的慢性脑血管狭窄或闭塞性疾病,其发生、发展是多种因素综合作用的结果,脑血管造影是诊断的金标准,药物和血管重建是现有的主要治疗措施。近年来,越来越多的研究显示血小板衍生生长因子(PDGF)和PDGF受体(PDGFR)在烟雾病的病因、发生和发展中扮演重要角色。目前较为一致的观点认为PDGF和PDGFR在血管方面具有重要作用,有望进一步揭示烟雾病的病因和发病机制,并且为临床上烟雾病的诊断、新型药物及基因治疗等方面提供新思路。Moyamoya disease is a kind of chronic cerebrovascular stenosis or occlusive disease,with unknown etiology.Its occurrence and development is the result of many factors.And cerebral angiography is the gold standard for the diagnosis,while medication and vascular reconstruction are the main therapeutic measures.In recent years,more and more studies showed that platelet derived growth factor(PDGF)and PDGF receptor(PDGFR)play an important role in the etiology,occurrence and development of moyamoya disease.The present view is that PDGF and PDGFR play an important role in the blood vessel,which is expected to further reveal the etiology and pathogenesis of moyamoya disease,and provide new ideas for the diagnosis,new drug and gene therapy etc.

关 键 词：烟雾病 血小板衍生生长因子 血小板衍生生长因子受体 

分 类 号：R651.1[医药卫生—外科学]