冠心病患者血清hsCRP水平和外周血单个核细胞CX3CR1的表达及其临床意义  

Serum hsCRP level and expression of CX3CR1 on peripheral blood mononuclear cells in patients with coronary heart disease and its clinical significance

作　　者：冯六六[1] 黄红漫[1] 刘新兵[1] 刘天华[1] 白艳艳[1] 史骏[1] 杨玉亚[1] 肖文颖[1] FENG Liu-liu;HUANG Hong-man;LIU Xin-bing;LIU Tian-hua;BAI Yan-yan;SHI Jun;YANG Yu-ya;XIAO Wen-ying(Department of Cardiology,Shidong Hospital of Yangpu District,Shanghai,200438,China)

机构地区：[1]上海市杨浦区市东医院心内科,上海市200438

出　　处：《心血管康复医学杂志》2018年第2期124-128,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

基　　金：上海市医学重点专科建设项目(ZK2015B23)~~

摘　　要：目的:探讨冠心病(CHD)患者血清高敏C反应蛋白(hsCRP)水平和外周血单个核细胞(PBMC)上CX3C趋化因子受体-1(CX3CR1)的表达及其意义。方法:选择2016年3月~2017年3月我院收治的153例CHD患者为研究对象,其中稳定型心绞痛(SAP)患者50例,不稳定型心绞痛(UAP)患者52例,急性心肌梗死(AMI)患者51例;根据Gensini积分评估的冠脉病变程度,153例CHD患者又被分为轻度病变组(43例)、中度病变组(56例)和重度病变组(54例)。选择同期45例体检健康者为健康对照组。测量比较各组血清hsCRP水平和PBMC上CX3CR1表达水平,分析血清hsCRP、CX3CR1表达水平与Gensini积分之间的相关性。结果:与健康对照组比较,SAP组、UAP组和AMI组的血清hsCRP水平[(2.36±1.67)mg/L比(5.07±2.16)mg/L比(13.59±5.23)mg/L比(27.46±8.24)mg/L]和PBMC上的CX3CR1表达[(0.48±0.25)%比(11.13±5.42)%比(20.56±9.73)%比(37.49±12.82)%]均显著升高,且AMI组>UAP组>SAP组,两两比较均有显著差异,P均=0.001。与轻度病变组比较,中度、重度病变组血清hsCRP水平[(6.31±1.83)mg/L比(17.42±6.58)mg/L比(35.26±9.74)mg/L]和PBMC上CX3CR1的表达[(6.59±1.43)%比(25.86±9.37)%比(42.57±13.28)%]均显著升高,且重度病变组的显著高于中度病变组,P均=0.001。直线相关分析显示,血清hsCRP水平、PBMC上的CX3CR1表达与Gensini积分呈显著正相关(r=0.768,0.897,P均=0.001)。结论:随着冠脉病变程度的加重,CHD患者血清hsCRP水平、CX3CR1表达显著升高,二者有望成为预测CHD疾病严重程度的参考指标。Objective:To explore serum level of high sensitive C reactive protein(hsCRP)and expression of CX3C chemokine receptor 1(CX3CR1)on peripheral blood mononuclear cells(PBMC)in patients with coronary heart disease(CHD)and its clinical significance.Methods:A total of 153 CHD patients treated in our hospital from Mar 2016 to Mar 2017 were selected,including 50 cases with stable angina pectoris(SAP),52 cases with unstable angina pectoris(UAP)and 51 cases with acute myocardial infarction(AMI);according to coronary lesion degree assessed by Gensini score,153 CHD patients were divided into mild coronary disease group(n=43),moderate coronary disease group(n=56)and severe coronary disease group(n=54).Another 45 healthy subjects were selected as healthy control group during the same period.Serum hsCRP level and CX3CR1 expression on PBMC were measured and compared among all groups,the correlation among serum hsCRP level,CX3CR1 expression and Gensini score were analyzed.Results:Compared with healthy control group,there were significant rise in serum hsCRP level[(2.36±1.67)mg/L vs.(5.07±2.16)mg/L vs.(13.59±5.23)mg/L vs.(27.46±8.24)mg/L]and CX3CR1 expression on PBMC[(0.48±0.25)%vs.(11.13±5.42)%vs.(20.56±9.73)%vs.(37.49±12.82)%]in SAP group,UAP group and AMI group,and AMI group>UAP group>SAP group,there was significant difference between any two groups,P=0.001 all.Compared with mild coronary disease group,there were significant rise in serum hsCRP level[(6.31±1.83)mg/L vs.(17.42±6.58)mg/L vs.(35.26±9.74)mg/L]and CX3CR1 expression on PBMC[(6.59±1.43)%vs.(25.86±9.37)%vs.(42.57±13.28)%]in moderate and severe coronary disease group,and those of severe coronary disease group were significantly higher than those of moderate coronary disease group,P=0.001 all.Linear correlation analysis indicated that serum hsCRP level and CX3CR1 expression on PBMC were significantly correlated with Gensini score(r=0.768,0.897,P=0.001 both).Conclusion:Serum hsCRP level and CX3CR1 expression significantly rise in CHD patients along with the

关 键 词：冠心病 C反应蛋白质 趋化因子 CX3C 

分 类 号：R541.409[医药卫生—心血管疾病]