MicroRNAs对血管损伤后的再狭窄和血栓形成的抑制  

Inhibition of microRNAs on restenosis and thrombosis after vascular injury

作　　者：余敏 孙勇[1] YU Min;SUN Yong(Department of Cardiology,Second Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang,150001,China)

机构地区：[1]哈尔滨医科大学附属第二医院心内科,黑龙江哈尔滨150001

出　　处：《心血管康复医学杂志》2018年第2期228-230,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：经皮冠脉介入治疗术(PCI)术后可能会发生再狭窄和支架内血栓形成,其如何抑制以改善预后,是个很大的挑战。MicroRNA的发现为此开拓了新视野,可通过调节microRNA来抑制再狭窄和支架内血栓形成。本文总结了microRNA在血管损伤后发挥作用的实验和临床证据,提示循环中的microRNA可作为抑制PCI术后再狭窄的生物标志物。Restenosis and in-stent thrombosis may occur after percutaneous coronary intervention(PCI),therefore,its inhibition and improvement of patient's prognosis is a big challenge.Discovery of microRNAs develops a new view for this.Restenosis and in-stent thrombosis may be inhibited through regulating microRNA.The present article summarized experimental and clinical evidence of microRNA playing role after vascular injury,suggest that circulating microRNA can be used as a biomarker for inhibiting restenosis after PCI.

关 键 词：微RNAS 血管成形术 气囊 冠状动脉 冠状动脉再狭窄 血栓形成 

分 类 号：R541.409[医药卫生—心血管疾病]