卡麦角林治疗女性高泌乳素血症性不孕的疗效分析  

A Study on the Treatment of Cabergoline in Female Patients with Hyperprolactinemia Infertility

作　　者：苏雅琴[1] 张宁宁[1] 梁小青[1] 张少静[1] 魏永志[1] SU Ya-qin;ZHANG Ning-ning;LIANG Xiao-qing;ZHANG Shao-jing;WEI Yong-zhi(Gynecology Department 2,Shijiazhuang First Hospital,Shijiazhuang 050011,China)

机构地区：[1]石家庄市第一医院妇科二病区,050011

出　　处：《国际妇产科学杂志》2018年第2期196-199,共4页Journal of International Obstetrics and Gynecology

基　　金：石家庄市科学技术研究与发展指导计划(151460723)

摘　　要：目的:分析卡麦角林治疗女性高泌乳素血症性不孕患者的临床疗效,探讨其应用价值。方法:回顾性分析石家庄市第一医院妇产科2013年6月—2017年6月诊治的女性高泌乳素血症性不孕患者病例资料,筛选出药物治疗者共109例,根据用药不同分为2组,观察组(48例)采用卡麦角林治疗,对照组(61例)采用溴隐亭治疗。记录并比较2组治疗后1个月、3个月、6个月血清泌乳素(PRL)水平变化情况、不孕症疗效、不良反应发生率以及耐药情况。结果:观察组患者治疗后1个月、3个月和6个月的血清PRL下降值均多于对照组,差异有统计学意义(均P<0.05)。观察组成功妊娠者多于对照组,差异有统计学意义(χ~2=5.068,P=0.024)。观察组恶心、呕吐和低血压的发生率均低于对照组,差异有统计学意义(均P<0.05)。观察组耐药率低于对照组,但差异无统计学意义(P>0.05)。结论:卡麦角林治疗女性高泌乳素血症性不孕患者降PRL效果较溴隐亭更好,成功妊娠率也更高,同时不良反应发生率更低。Objective:To explore the treatment efficacy of cabergoline in women with hyperprolactinemia infertility.Methods:109 cases of hyperprolactinemia infertility in our department of obstetrics and gynecology from June 2013 to June 2017 were analyzed retrospectively.The observation group(n=48)was treated with cabergoline,and the control group(n=61)was treated with bromocriptine.The serum PRL of 1,3 and 6 months after the treatment in two groups,the treatment effect of infertility,the incidence of adverse reactions and drug resistance were recorded.Results:The serum PRL decline values of the observation group were more than those of the control group at 1 month,3 months and 6 months after the treatment(P<0.05).The cases of successful pregnancy in the observation group were more than those in the control group,and the difference was statistically significant(χ2=5.068,P=0.024).The incidence of nausea&vomiting and hypotension in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05).The drug resistance rate of the observation group was lower than that of the control group(P>0.05).Conclusions:In the treatment of hyperprolactinemia infertility,the treatment effect of cabergoline is better than that of the bromocriptine in reducing prolactin and the improvement of pregnancy rate,while the incidence of severe adverse reactions is lower.

关 键 词：高催乳素血症 不育 女(雌)性 溴隐亭 卡麦角林 

分 类 号：R711.6[医药卫生—妇产科学]