骨质疏松动物模型的研究进展及文献回顾  

Research progress and literature review of animal models of osteoporosis

作　　者：李延红 党晓谦[2] 龚福太 班文瑞 马骏[2] 石耀武 张宏蕾 Li Yan-hong;Dang Xiao-qian;Gong Fu-tai;Ban Wen-rui;Ma Jun;Shi Yao-wu;Zhang Hong-lei(Xi’an Hospital of Chinese Medicine,Xi’an 710021,Shaanxi Province,China;the Second Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,Shaanxi Province,China)

机构地区：[1]西安市中医医院,陕西省西安市710021 [2]西安交通大学第二附属医院,陕西省西安市710061

出　　处：《中国组织工程研究》2018年第12期1956-1961,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:骨质疏松症被称为"静悄悄的流行病"、是吞噬老年人健康的"隐形杀手"。骨质疏松最危险的并发症是骨折,骨质疏松症引发的骨折不仅是医学界急需解决的问题,也是一个严重的社会问题。目的:就骨质疏松模型动物的选择、造模方法、各种动物模型的特点及评价方式做以综述。方法:计算机检索中国生物医学文献数据库、万方中文数据库、维普中文科技期刊数据库和PubM ed数据库1986年1月至2016年12月,设定"骨质疏松,动物模型"和"osteoporosis,animal models"为检索词,通过阅读标题和摘要进行筛选,最后保留39篇文章进行分析讨论。结果与结论:(1)实验动物在骨质疏松症的研究中发挥着重要作用,动物模型的设计应符合相似性、可靠性、重复性、适用性、可控性、易行性和经济性的原则;(2)因骨质疏松症是一种进展性、病程长的疾病,不同阶段各有其特点,一种动物模型一般只侧重于表现该疾病的某种病因、某一阶段、某些主要症状及某些病理生理变化,而不能完全复制人类疾病的病理变化过程;(3)目前的研究显示,动物种类和造模方法影响模型的特征,动物年龄、饲养方式、造模时间及模型判定标准的选择等方面尚缺乏统一的标准。BACKGROUND:Osteoporosis,known as“a quiet epidemic disease”,is an“invisible killer”that impairs the health of the elderly.Fracture as the most dangerous complication of osteoporosis is not only a medical problem,but also a serious social problem.OBJECTIVE:To summarize the selection,establishment methods,characters and evaluation of the animal model of osteoporosis.METHODS:A computed-based search of CBM,WanFang,VIP,CNKI and PubMed databases was conducted for the relevant articles published from January 1986 to December 2016 using the keywords of“osteoporosis,animal models”in English and Chinese,respectively.Finally 39 articles were included for result analysis after reading the title and abstract.RESULTS AND CONCLUSION:Animal experiments play an important role in the studies of osteoporosis,so a desirable animal model should hold similarity,reliability,repeatability,applicability,controllability,efficacy and economy.Osteoporosis is a progressive and long-lasting disease that has different characteristics at different stages.But an animal model only simulates one etiology,one stage,major symptoms and pathophysiological changes,and cannot exhibit the whole pathological changes.The current study suggests that animal species and modeling methods can affect the characters of models,and there is a lack of standards for animal age,feeding methods,modeling time and assessment.

关 键 词：骨质疏松症 动物模型 研究进展 文献回顾 组织构建 骨质疏松 模型 动物 组织工程 

分 类 号：R318[医药卫生—生物医学工程]