卵巢癌动物模型制备的研究进展  

Research progress on establishment of animal models of ovarian cancer

作　　者：李冬冬 王莉[1] 钟洁[1] 凌晨祁[1] 梁延平[1] LI Dongdong;WANG Li;ZHONG Jie;LING Chenqi;LIANG Yanping(Department of Gynecology,East City Hospital of Shanghai Yangpu District,Shanghai 200438,China)

机构地区：[1]上海市杨浦区市东医院妇科,上海200438

出　　处：《中国实验动物学报》2018年第2期259-264,共6页Acta Laboratorium Animalis Scientia Sinica

基　　金：杨浦区肿瘤预防专项行动计划与上海市东医院院级课题(No.2016YKT010)联合资助~~

摘　　要：卵巢癌是导致女性癌症死亡的第五大原因,其中75%的卵巢癌患者检出时即为晚期。目前该病缺乏有效的早期筛查手段,同时临床治疗效果较差,已经成为严重威胁妇女健康的重大疾病。借助卵巢癌动物模型开展相关研究工作,是阐明其发病机制或者筛选有效的诊断、治疗措施的重要手段。目前,按照制备方法分类,该疾病模型主要分为有自发型、诱发型、移植型、基因干预型等四类造模方法。该模型所选择的动物主要有小鼠、大鼠、鸡、东方田鼠、长爪沙鼠等。本文结合近年来的文献报道,综述了卵巢癌动物模型制备方法,并介绍了各种方法制备的动物模型的评价标准及主要特点。Ovarian cancer is the fifth leading cause of cancer-related death in women.75%of ovarian cancer patients were detected at an advanced stage.At present,the disease lacks effective early screening method and the clinical therapy effect is poor,which has become a serious threat to women’s health.The use of animal models of ovarian cancer is an important mean to elucidate the pathogenesis of the disease,and to screen effective diagnosis and treatment.The disease models are mainly divided into four types:spontaneous,induced,transplanted and gene intervention type.Mice,rats,hens,Mirotus Fortis and Mongolian gerbil are mainly selected to prepare animal models of ovarian cancer.Based on recent literature reports,we reviewed the preparation method of animal models of ovarian cancer and introduced the evaluation standards and main characteristics of these animal models.

关 键 词：卵巢癌 动物模型 制备方法 研究进展 

分 类 号：Q95-33[生物学—动物学]