慢性心力衰竭患者肾功能指标水平及其与心功能的相关性分析  

Correlation analysis of blood renal function index and cardiac function in patients with chronic heart failure

作　　者：张德龙[1] 宋金玲[2] 王世峰 孙伟[1] 宫玉霞[1] 李智[1] ZHANG Delong;SONG Jinling;WANG Shifeng;SUN Wei;GONG Yuxia;LI Zhi(Department of Cardiology,Third People's Hospital of Dalian,Dalian 116031,China)

机构地区：[1]大连市第三人民医院心内科,116031 [2]大连市第三人民医院急诊内科,116031

出　　处：《疑难病杂志》2018年第4期343-346,共4页Chinese Journal of Difficult and Complicated Cases

摘　　要：目的观察慢性心力衰竭患者的肾功能指标水平,并分析其与心功能的相关性。方法选取2016年2月—2017年5月大连市第三人民医院心内科治疗的慢性心力衰竭患者60例作为研究对象(观察组),同时选取同期医院接受体检的健康成年人60例作为健康对照组。观察2组对象肾功能指标(NGAL、SCr、BUN)、心功能指标(CK、NT-pro BNP、CTn I、LAD、RAD、LVEF)的差异,分析肾功能水平与心功能指标的相关性。结果观察组患者的NGAL、SCr和BUN水平均高于健康对照组(t=-12.698、-38.127、-30.101,P=0.000);观察组患者的血CK、NTpro BNP、CTn I、LAD、RAD水平均高于健康对照组(t=-39.546、-83.814、-54.707、-27.844、-14.713,P=0.000),LVEF低于健康对照组(t=16.514,P=0.000);慢性心力衰竭患者的NGAL、BUN、SCr水平与NT-pro BNP、LAD、RAD呈正相关(分别为r=0.536、0.613、0.602、0.526;r=0.513、0.618、0.631、0.478;r=0.498、0.524、0.515、0.512,P均<0.05),与LVEF水平呈负相关(r=-0.406、-0.518、-0.475,P<0.05)。结论慢性心力衰竭患者的血NGAL、SCr和BUN水平均较高,且与患者的心功能等指标密切相关,可作为监测的重要指标。Objective To observe the level of blood and kidney function in patients with chronic heart failure and analyze its correlation with cardiac function.Methods 60 cases of chronic heart failure treated in Department of Cardiology,Third People's Hospital of Dalian City,from February 2016 to May 2017(observation group)were selected as the research object,and the healthy adults who underwent physical examination in our hospital were selected as the control group.The differences of renal function levels,such as NT proBNP and other myocardial enzymes and BUN were observed in 2 groups.The difference of cardiac function between 2 groups was compared,and the correlation between renal function level and cardiac function index was analyzed.Results The levels of NGAL,SCr and BUN in the observation group were all higher than those in the control group(P=0.000).The levels of serum creatine kinase,NT proBNP and CTnI in patients with chronic heart failure were higher than those in the control group(P=0.000).The LAD and RAD of the patients with chronic heart failure were higher than those of the control group(P=0.000),and the LV EF was lower than that of the control group(P=0.000).NGAL,BUN,SCr positive,LAD level and NT proBNP and RAD in patients with chronic heart failure(r=0.536,r=0.613,r=0.602,r=0.526,r=0.513,r=0.618,r=0.631,r=0.478,r=0.498,r=0.524,r=0.515,r=0.512,P<0.05)were negatively correlated with LV EF level(r=0.406,r=0.518,r=0.475,P<0.05).Conclusion The levels of blood NGAL,SCr,BUN in patients with chronic heart failure are higher,which are closely related to the cardiac function of patients,and can be used as an important indicator for monitoring.

关 键 词：心力衰竭 慢性 微量蛋白 心功能 肾功能 

分 类 号：R541.6[医药卫生—心血管疾病]