亮白光LED结合古典音乐疗法的抗抑郁效果（英文）  

Antidepressant effect of bright white LED combined with classical music

作　　者：王丹妮[1] 代玉环 程静 张大伟[1] 王成[2] 庄松林[1] Wang Danni;Dai Yuhuan;Cheng Jing;Zhang Dawei;Wang Cheng;Zhuang Songlin(School of Optical-Electrical and Computer Engineer,University of Shanghai for Science and Technology, Shanghai 200093,China;Institute of Biomedical Optics and Optometry Optics,University of Shanghai for Science and Technology,Shanghai 200093,China)

机构地区：[1]上海理工大学光电信息和计算机工程学院,上海200093 [2]上海理工大学生物医学与视光学研究所,上海200093

出　　处：《红外与激光工程》2018年第4期261-266,共6页Infrared and Laser Engineering

基　　金：国家重点研发计划(2016YFB1102300);国家973项目(2015CB352001);国家自然科学基金(61378060)

摘　　要：通过小鼠实验提出了一种亮白光LED联合古典音乐疗法。遭受过慢性不可预知性应激的小鼠被随机分成3组,均饲养在350 lx、光周期为12小时明亮12小时黑暗的环境中。对照组(C):不做任何处理。五行音乐组(M):每天播放2个小时古典音乐。五行音乐+光照组(M+B):每天播放2小时古典音乐并采用5 000 lx的白光LED照射。30天后用糖水偏爱度测试和强迫游泳实验来评估抑郁程度。与C组相比,M和M+B组的小鼠表现出更短的游泳不动时间和更长的游泳和攀爬时间(p<0.001)。M+B组小鼠的游泳不动时间(52.3±25.18 s)要短于M组(78.9±14.82 s),且差异存在统计学意义(t(9)=3.414,p=0.008<0.05)。亮白光LED联合古典音乐疗法能够提高应激小鼠的活力,具有一定的抗抑郁作用。The treatment of bright white LED combined with classical music was proposed by laboratory mice.Mice suffered from chronic mild stress were divided randomly into three groups and exposed to 12:12 h bright light:dark(350 lx)conditions.The control group(C)received no treatment.The classical music group(M)was treated with classical music of 2 h per day.The classical music+bright light group(M+B)was treated daily with classical music of 2 h and 5 000 lx white LED light.Thirty days later,depression-like behaviors were assessed using saccharin solution preferences and forced swim tests.Mice in M and M+B demonstrated signi cantly shorter immobility times and longer climbing times and swimming times compared to those in C(p<0.001).It was observed that M+B experienced shorter immobility times(52.3±25.18 s)than M(78.9±14.82 s),and there was significant difference between two groups(t(9)=3.414,p=0.008<0.05).The combination therapy of bright white LED and classical music raised the vitality of mice and possessed antidepressant effect.

关 键 词：亮白光LED 古典乐 抑郁症 光周期 

分 类 号：R454.2[医药卫生—治疗学]