生白术化学成分研究  

Chemical Constituents of Rhizomes of Atractylodes macrocephala

作　　者：李滢[1,2] 杨秀伟 LI Ying;YANG Xiu-wei(State Key Laboratory of Natural and Biomimetic Drugs,Peking University,Beijing 100191,China;Department of Natural Medicines,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China)

机构地区：[1]北京大学天然药物及仿生药物国家重点实验室,北京100191 [2]北京大学药学院天然药物学系,北京100191

出　　处：《中国现代中药》2018年第4期382-386,共5页Modern Chinese Medicine

基　　金："十二五"国家科技支撑计划(2011BAI07B08)

摘　　要：目的:研究生白术的化学成分。方法:采用硅胶柱色谱方法对化学成分进行分离纯化,通过质谱、核磁共振等谱学数据鉴定化合物结构。结果:从生白术环己烷提取物中分离并鉴定了9个化合物,分别为苍术酮(1),白术内酯Ⅰ(2),双白术内酯(3),白术内酯Ⅱ(4),白术内酰胺(5),白术内酯Ⅲ(6),4R,15-环氧白术内酯Ⅱ(7),4R,15-环氧-8β-羟基白术内酯Ⅱ(8),8β,9α-二羟基白术内酯Ⅱ(9)。结论:化合物7为新的天然产物,化合物9为首次从中药白术中分离鉴定。Objective:To study the chemical constituents of the rhizomes of Atractylodes macrocephala.Methods:Repeated column chromatography on silica gel and HPLC were applied to the separation of compounds and their structures were determined by spectroscopic data analyses of MS and NMR.Results:Nine compounds were obtained and identified as atractylon(1),atractylenolideⅠ(2),biatractylenolide(3),atractylenolideⅡ(4),atractylenolactam(5),atractylenolideⅢ(6),4 R,15-epoxylatractylenolideⅡ(7),4 R,15-epoxy-8β-hydroxylatractylenolideⅡ(8),and 8β,9α-dihydroxylatractylenolideⅡ(9),respectively.Conclusion:Compound 7 was a new natural product and compound 9 was isolated from the rhizomes of A.macrocephala for the first time.

关 键 词：白术 化学成分 4 R 15-环氧白术内酯Ⅱ 8β 9α-二羟基白术内酯Ⅱ 

分 类 号：R284.1[医药卫生—中药学]