二甲基甲酰胺急性中毒的临床治疗分析  

Analysis of Clinical Treatment of Dimethylformamide Acute Poisoning

作　　者：叶锦山[1] YE Jin-shan(Department of Emergency,Xiamen Hospital of Traditional Chinese Medicine,Xiamen,Fujian Province,361009 China)

机构地区：[1]厦门市中医院急诊科,福建厦门361009

出　　处：《中外医疗》2018年第7期108-111,共4页China & Foreign Medical Treatment

摘　　要：目的分析二甲基甲酰胺急性中毒的临床检查及治疗情况。方法回顾性分析该院2015年5月—2017年5月收治的8例二甲基甲酰胺急性中毒患者临床资料,对8例患者的临床资料进行分析,包括临床症状、体征、实验室检查、常规检查等结果,根据分析的结果及患者中毒情况为其实施合理的综合治疗,观察8例患者经治疗后疾病归转情况。结果 8例急性二甲基甲酰胺中毒患者中毒时间均集中于4~11月,中毒原因以皮肤直接接触及呼吸道意外吸入为主,患者均表现出以上腹部疼痛为主的伴恶心呕吐、头晕头痛、腹胀等临床症状,实验室检查发现患者均存在不同程度的肝功能损害,为患者实施护胃、保肝、降酶等一系列综合治疗后,有6例患者痊愈出院,且未发生后遗症,1例患者病情恶化,1例患者出现并发症。结论急性二甲基甲酰胺中毒好发于夏秋季节,应加强季节性的防护,且患者在中毒后将诱发中毒性肝病,均存在不同程度的肝功能损害,应及时给予患者降酶、保肝等综合治疗,以保证临床救治效果理想,帮助患者预后改善。Objective This paper tries to analyze the clinical examination and treatment of dimethylformamide(DMF)acute poisoning.Methods The clinical data of 8 cases of DMF acute poisoning in this hospital from May 2015 to May 2017 were retrospectively analyzed,including clinical symptoms,signs,laboratory examination and routine examination.The patients were given reasonable comprehensive treatment according to the analysis result and poisoning conditions.The disease outcome of 8 cases of patients after treatment were observed.Results The poisoning time of 8 cases of DMF acute poisoning mainly focused from April to November,the main poisoning reasons were direct contact with skin or accidental respiratory inhalation,and patients appeared upper abdominal pain with nausea and vomiting,dizziness or headache,abdominal distension;the laboratory examination showed that the patients had different degrees of liver function impairment,and they were given comprehensive treatment of preserving stomach,protecting liver and degrading enzyme,after treatment,there were 6 cases were cured and discharged without sequela,1 case with deterioration and 1 case with complications.Conclusion DMF acute poisoning easily occurs in summer and autumn,so that it is necessary to strengthen seasonal protection.After poisoning,patients easily have toxic hepatic disease and different degrees of liver function impairment,and they should be immediately given comprehensive treatment of degrading enzyme and protecting liver,so as to achieve satisfactory rescue effects and improve patients’prognosis.

关 键 词：二甲基甲酰胺 急性中毒 治疗 

分 类 号：R4[医药卫生—临床医学]