基于“培土生金”理论探讨生长激素释放肽-肥胖抑制素系统对慢性阻塞性肺疾病合并营养不良的调节作用  

Discussion on Regulating Effects of Ghrelin-Obestatin System in COPD with Malnutrition Based on “Reforcing Earth to Generate Metal” Theory

作　　者：桑凯 孙杰[1,2] 马泉 王东晓[1] SANG Kai;SUN Jie;MA Quan;WANG Dong-xiao(Gansu University of Chinese Medicine,Lanzhou 730000,China;Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730020,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃中医药大学附属医院,甘肃兰州730020

出　　处：《中国中医药信息杂志》2018年第5期6-9,共4页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金地区基金(81360539);甘肃省财政厅科研业务费项目(2013-9);兰州市科技局项目(2012-1-56)

摘　　要：现代医学研究发现,生长激素释放肽(ghrelin)与肥胖抑制素(obestatin)作为胃肠道激素,能通过影响机体的营养状态而参与慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)的发病,使用药物调节ghrelin-obestatin系统可以通过改善COPD患者的营养状况而利于疾病的治疗。这与中医学"培土生金"理论中通过调补中州、充实后天从而达到滋养肺金的观点不谋而合,而ghrelin-obestatin系统作为中西医学理论相互交融的共通点,探讨其在调节COPD合并营养不良中的作用与中医学"培土生金"理论的关系,对于科学阐释中医药治疗本病有启示意义。According to modern medical research,ghrelin and obestatin,as gastrointestinal hormones,have been involved in the pathogenesis of COPD by influencing the nutritional status of the organism.Using medicine to regulate ghrelin-obestatin system can benefit the treatment of the disease by improving the nutritional status of patients with COPD.It coincides with the TCM“reforcing earth to generate metal”theory by transfering of Zhongzhou,enriching the nurture to nourish the lung.Ghrelin-obestatin system,as a common point of the blend of Chinese and Western medicine theory,is to explore its role in the regulation of COPD with malnutrition and the relationship of TCM“reforcing earth to generate metal”theory,which has implications for scientific interpretation of TCM in the treatment of this disease.

关 键 词：培土生金 生长激素释放肽 肥胖抑制素 慢性阻塞性肺疾病合并营养不良 

分 类 号：R259.63[医药卫生—中西医结合]