2型糖尿病并发骨质疏松症的相关因素  

Factors of Osteoporosis in Type 2 Diabetes Mellitus

作　　者：杨一峰 李艳波[1] YANG Yifeng;LI Yanbo(Department of Endocrinology,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院内分泌科,哈尔滨150001

出　　处：《医学综述》2018年第8期1586-1589,1595,共5页Medical Recapitulate

摘　　要：骨质疏松症是糖尿病的并发症之一,近年来其发病率有逐年升高的趋势,而糖尿病也增加了骨质疏松的治疗难度。糖尿病并发骨质疏松症的机制较复杂。影响糖尿病并发骨质疏松的因素有很多,包括晚期糖基化终末产物、胰岛素水平、胰岛素样生长因子、血糖代谢异常等,降糖药物也影响骨质疏松的发生,其中胰岛素、二甲双胍等是保护因素,而噻唑烷二酮类促敏剂是风险因素。深入研究影响骨质疏松发生的因素可指导疾病的治疗和预防,提高患者的生活质量。Osteoporosis is one of the complications of diabetes.In recent years,its incidence has been increasing year by year.Diabetes also increases the difficulty of osteoporosis recovery.The mechanism of diabetes complicated with osteoporosis is more complex.There are many factors which can influence diabetes mellitus complicated with osteoporosis,including advanced glycation end products,insulin level,insulin-like growth factors,abnormal blood glucose metabolism and so on,and hypoglycemic drugs also affect the occurrence of osteoporosis,among which insulin and melbine are the protective factors and thiazolidinediones are the risk factors.Further research on the influence factors can guide the treatment and prevention of the disease and improve the quality of life of the patients.

关 键 词：糖尿病 骨质疏松症 骨密度 晚期糖基化终末产物 胰岛素 胰岛素样生长因子 

分 类 号：R589.5[医药卫生—内分泌]