手性苯乙醇的制备  

Preparation of Chiral Phenylethanol

作　　者：邹胜 黄晴菲[2] 黄文才[1] 朱槿[2] ZOU Sheng;HUANG Qing-fei;HUANG Wen-cai;ZHU Jin(College of Chemical Engineering,Sichuan University,Chengdu 610065,China;Chengdu Organic Chemical Co.,Ltd.,Chengdu 610041,China)

机构地区：[1]四川大学化学工程学院,四川成都610065 [2]中国科学院成都有机化学有限公司,四川成都610041

出　　处：《合成化学》2018年第4期288-291,共4页Chinese Journal of Synthetic Chemistry

摘　　要：以邻苯二甲酸酐和外消旋a-苯乙醇为原料,制得2-(1-苯乙氧羰基)苯甲酸(3);3依次与手性苯乙胺成盐、重结晶和水解,制备了(R)-1-苯乙醇和(S)-1-苯乙醇,光学纯度大于99%,总收率42.5%,其结构经~1H NMR和GC确证。2-(1-Phenethyloxycarbonyl)benzoic acid(3)was obtained by the reaction of racemic 1-phenylethanol with phthalic anhydride.The chiral R-1-phenylethanol and S-1-phenylethanol,with total yield of 42.5%and ee>99%,were prepared by salt formation of 3 with chiral 1-phenylethylamine,recrystallization and hydrolyzation.The structures were confirmed by 1 H NMR and GC.

关 键 词：苯乙醇 邻苯二甲酸酐 2-(1-苯乙氧羰基)苯甲酸 手性 制备 

分 类 号：O626.4[理学—有机化学] O621.3[理学—化学]