α-重氮膦酸酯作为亲核试剂参与不对称反应的研究进展  

Research Progress of Asymmetric Reactions byα-Diazophosphonates as Nucleophile

作　　者：杜太平 DU Tai-ping(PKU Health Care Co.,Ltd.,Chongqing 400700,China)

机构地区：[1]北大医药股份有限公司,重庆400700

出　　处：《合成化学》2018年第4期307-311,共5页Chinese Journal of Synthetic Chemistry

摘　　要：重氮化合物作为一类重要的合成子,在有机合成、药物化学、材料化学及化学生物学等领域均有广泛应用。α-重氮膦酸酯作为α-重氮羧酸酯的电子等排物,可作为亲核试剂参与不对称反应。综述了α-重氮膦酸酯作为亲核试剂参与不对称反应(Mannich反应,Morita-Baylis-Hillman反应,类Aldol反应以及[3+2]反应)的研究进展,并对其未来发展进行了展望。Diazo compounds,as an important synthon,have been widely used in synthetic chemistry,pharmaceutical chemistry,material chemistry and chemical biology.α-Diazophosphonates,the isostere of diazo carboxylate,could apply to asymmetric reactions as nucleophiles.The aim of this paper is introducing the recent progress in the asymmetric reactions,including Mannich reaction,Morita-Baylis-Hillman type reaction,Aldol type reaction and[3+2]reaction,involvingα-diazophosphonates as nucleophiles.The challenges it faces was summarized and the future development was prospected as well.

关 键 词：重氮化合物 α-重氮膦酸酯 亲核试剂 不对称反应 综述 

分 类 号：O621.3[理学—有机化学]